在牛皮性关节炎中阻塞性睡眠呼吸暂停:基于多睡眠学的评估
Mohammad Mustafa1, Suzan Attar2, Omar Kanbr3,4
1Rheumatology Unit, Department of Medicine, University of Jeddah, Jeddah, Saudi Arabia.
Medicine
|November 8, 2025
概括
阻塞性睡眠呼吸暂停 (OSA) 影响了50%的牛皮关节炎 (PsA) 患者,年龄较大和BMI较高是关键预测因素. 没有发现OSA和PsA疾病活动之间的联系.
科学领域:
- 类风湿病学 类风湿病学
- 睡眠医学 睡眠医学
- 流行病学 流行病学
背景情况:
- 阻塞性睡眠呼吸暂停 (OSA) 是一种普遍存在的全球疾病,对健康有重大影响.
- 在被诊断患有牛皮关节炎 (PsA) 的患者中,OSA的患病率尚未确立.
- 牛皮关节炎 (PsA) 是一种慢性炎症性疾病,影响关节和皮肤.
研究的目的:
- 在患有牛皮关节炎 (PsA) 的患者中确定阻塞性睡眠呼吸暂停 (OSA) 的点患病率.
- 探索OSA和PsA疾病活动之间的潜在关联.
- 在PsA群体中确定OSA的预测因子.
主要方法:
- 使用了OSA诊断的黄金标准 - - 多睡眠学图 (PSG).
- 诊断OSA遵循美国睡眠学会 (AASM) 的指导方针.
- 使用银病关节炎的疾病活动指数 (DAPSA) 和健康评估问卷-残疾指数 (HAQ-DI) 评估了PsA疾病活性.
主要成果:
- 在42名PsA患者中,OSA的点患病率为50%,其中36%患有中度至重度OSA.
- 在OSA和PsA疾病活性 (DAPSA或HAQ-DI) 之间没有发现显著的关联.
- 年龄较大 (OR=1.17) 和BMI较高的趋势 (OR=1.23) 预测了PsA患者的OSA.
结论:
- 患有牛皮关节炎的患者表现出阻塞性睡眠呼吸暂停的高患病率.
- 在PsA患者中,OSA看起来独立于疾病活动.
- 年龄较大和BMI较高是该人群中OSA的重要预测因素.
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