转化生长因子-β1作为恶性行为和PD-L1表达的生物标志物在胸膜上皮瘤中
Chiaki Nakazono1, Satoru Okada1,2, So Tando3
1Division of Thoracic Surgery, Department of Surgery, Graduate School of Medical Science, Kyoto Prefectural University of Medicine, Kyoto, Japan.
Cancer science
|November 8, 2025
概括
在胸膜上皮瘤 (TETs) 中转化生长因子β1 (TGF-β1) 的高表达表明有侵略性的疾病和不良的无复发生存率. 结合TGF-β1和编程死亡连接体1 (PD-L1) 的表达,完善了TETs的预后风险分层.
科学领域:
- 在瘤学瘤学.
- 免疫学 免疫学 免疫学
- 分子生物学分子生物学
背景情况:
- 胸膜上皮瘤 (TET) 进展的临床意义和分子机制尚不清楚.
- 转变生长因子-β1 (TGF-β1) 和编程死亡配体1 (PD-L1) 涉及瘤行为,但它们在TET中的作用需要阐明.
研究的目的:
- 评估TETs中TGF-β1的预后值.
- 研究TETs中TGF-β1和PD-L1表达之间的关系.
- 探索将TGF-β1与PD-L1表达联系起来的分子机制.
主要方法:
- 对92个手术切除的TET (79个胸腺瘤,13个胸腺癌) 的回顾性分析.
- 对TGF-β1,PD-L1,psmad2和psmad3表达的免疫组织化学评估.
- 在体外研究中,使用受TGF-β1.1.治疗的胸腺癌细胞系进行了实验.
主要成果:
- 高TGF-β1表达 (28%的患者) 与先进的马索卡阶段,较短的瘤翻倍时间和较低的5年无复发率 (FFR) 相相关.
- 高TGF-β1和PD-L1的同时表达预测了最差的预后 (5年FFR:46.1%),并且是一个独立的复发预测因子.
- 通过Smad信号传递 (pSmad2/3激活),TGF-β1在体外上调了PD-L1表达.
结论:
- 高TGF-β1表达定义了一个侵略性的TET表型.
- 结合TGF-β1和PD-L1表达改善了TETs的术后风险分层.
- 准TGF-β1和PD-L1通路可能是TETs的潜在治疗策略.
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