脉冲的形状:脉冲宽度和电流方向对使用Cobot辅助可控制的跨磁刺激装置引起的运动潜力的影响
Mirja Osnabruegge1, Florian Schwitzgebel2, Carolina Kanig1
1Institute of Psychology, University of the Bundeswehr Munich, Neubiberg, Germany; Department of Psychiatry and Psychotherapy, University of Regensburg, Regensburg, Germany.
优化跨磁刺激 (TMS) 需要调整脉冲宽度和电流方向. 较短的脉冲更节能,而电流方向影响了电机唤起潜能 (MEP) 的有效性.
科学领域:
- 神经科学是一个神经科学.
- 生物医学工程 生物医学工程
背景情况:
- 跨磁刺激 (TMS) 是一种非侵入性脑刺激技术.
- 可控制的TMS (cTMS) 带有cobot辅助的神经导航,可以准确地放置线圈.
- 该系统可以调节脉冲宽度和电流方向.
研究的目的:
- 研究电流方向和脉冲宽度对电机唤起电位 (MEP) 的影响.
- 使用cTMS设备评估不同刺激参数的有效性.
主要方法:
- 30名健康参与者从第一个背部骨肌中进行了MEP记录.
- 使用了具有不同持续时间 (280μs,160μs) 和方向 (PA,AP) 的双相脉冲.
- 在三种条件下,在110%的静止电机值 (RMT) 上进行了100次脉冲.
主要成果:
- 刺激被很好地容忍,没有任何不良事件.
- 较短的脉冲宽度需要较少的刺激强度来产生相同的反应,这表明效率更高.
- 前后 (AP) 当前方向对于门的欧洲议员来说,比前后 (PA) 更有效.
结论:
- TMS结果受到当前方向和脉冲宽度的显著影响.
- 较短的脉冲提供了更节能的刺激协议.
- 参数优化对于提高TMS可靠性和可比性在研究和临床环境中至关重要.
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