复杂的创伤后应激障碍在精神病患者中缓和了功能连接
Peter Panayi1, Filippo Varese1, Emmanuelle Peters2
1Division of Psychology and Mental Health, Manchester Academic Health Sciences Centre, University of Manchester, Manchester, UK; Complex Trauma and Resilience Research Unit, Greater Manchester Mental Health NHS Foundation Trust, Manchester, UK.
Psychiatry research. Neuroimaging
|November 8, 2025
概括
精神病中复杂的创伤后应激障碍 (cPTSD) 与关键网络内和关键网络之间大脑连接的改变有关. 这些发现表明,创伤后续可能会导致一些精神病患者的功能失联.
科学领域:
- 神经科学是一个神经科学.
- 精神病学是一个精神病学.
- 医疗成像医学成像
背景情况:
- 在精神病中观察到默认模式 (DMN),突出 (SAL) 和中央执行 (CEN) 网络中功能连接的改变.
- 创伤性生活经历会影响精神病中的功能连接.
- 复杂的创伤后应激障碍 (cPTSD) 与精神病中创伤史有关,但其对功能性失联性的影响尚未被探索.
研究的目的:
- 为了调查精神分裂症谱系障碍与并发性cPTSD和无并发性cPTSD的功能连接差异.
- 探索cPTSD症状严重程度与网络连接之间的关系.
主要方法:
- 休息状态fMRI被用来比较精神分裂症患者的功能连接性 (N=106) 和没有并发性cPTSD.
- 评估了DMN,SAL和CEN内部和之间的连接性.
- 相关性检查了cPTSD症状严重程度和连接性之间的联系.
主要成果:
- 在cPTSD组中,网络内部连接性 (DMN,SAL,CEN) 降低,SAL和CEN之间的反相关性增加.
- 对照组显示DMN,SAL和CEN之间的连接性下降.
- PTSD症状与SAL内部和DMN-SAL连接相关,而DSO症状与SAL内部和DMN-CEN连接相关.
结论:
- 这些发现支持心理病理学的三方网络模型,涉及DMN,SAL和CEN失联.
- 精神病中的内部网络失联可能与创伤后后果有关.
- 网络间的不连接可能更适用于与创伤无关的精神病.
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