多重负面情绪在慢性呼吸系统疾病中的因果作用:一个双样本的门德尔随机研究
Hui Chen1, Jinping Zhu1, Zewen Yang1
1Department of Respiratory and Critical Care Medicine, Shenzhen Bao'an District Songgang People's Hospital, Shenzhen, People's Republic of China.
Clinics (Sao Paulo, Brazil)
|November 8, 2025
概括
诸如神经病症之类的负面情绪因果上会增加患喘,慢性阻塞性肺病 (COPD) 和睡眠呼吸暂停综合征的风险. 针对情绪健康的早期干预可能有助于预防这些慢性呼吸道疾病.
科学领域:
- 遗传学 是一个遗传学.
- 流行病学 流行病学
- 精神病学是一个精神病学.
背景情况:
- 负面情绪状态和慢性呼吸道疾病之间的联系还不太清楚.
- 这项研究使用门德尔随机化 (MR) 来探索潜在的因果关系.
研究的目的:
- 研究各种负面情绪与患慢性呼吸道疾病的风险之间的因果关系.
- 确定导致喘,COPD和睡眠呼吸暂停综合征等疾病的特定情绪因素.
主要方法:
- 从IEU开放的GWAS数据库中利用公开的GWAS总结统计数据.
- 分析了12种负面情绪和6种慢性呼吸道疾病的数据,使用了5种MRI模型.
- 使用敏感性分析 (Leave-one-out,MR-PRESSO,Cochran's Q) 来评估异质性和性.
主要成果:
- 证实了消极情绪与慢性呼吸道疾病之间的因果关系.
- 神经症,情绪波动,紧张和担忧与喘风险增加有关.
- 神经症,痛苦,情绪波动,内和长时间的担忧与更高的COPD风险有关.
- 神经症,情绪波动和疼痛感增加了睡眠呼吸暂停综合征的风险.
- 对于支气管切开症,IPF或肉类突症,没有发现因果关系.
结论:
- 建立了负面情绪对慢性呼吸道疾病的因果关系.
- 强调了早期对负面情绪的干预对于预防呼吸系统疾病的重要性.
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