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德克萨米他诱导的免疫抑制在Pneumocystis肺炎中重编程中性粒细胞代谢,并损害抗菌功能

Xiao-Xia Zhou1, Yu-Xi Chen2, Dong Wang3

  • 1Department of Respiratory and Critical Care Medicine, Beijing Institute of Respiratory Medicine and Beijing Chao-Yang Hospital, Capital Medical University, Beijing, 100020, China; Department of General Medicine, Fu Xing Hospital, Capital Medical University, Beijing, 100038, China.

Biochemical and biophysical research communications
|November 8, 2025
PubMed
概括

德克萨米他 (DEX) 通过抑制脂肪酸氧化 (FAO) 来损害在肺囊炎肺炎 (PCP) 中的中性粒细胞功能. 这种代谢重编程降低了中性粒细胞的抗菌能力,在机会性感染期间恶化了免疫抑制.

关键词:
德克萨米他是一种脂肪酸氧化过程中的脂肪酸氧化.作为一个中性粒细胞.肺囊性肺炎是一种肺炎.

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