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Updated: Jan 12, 2026

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StealTHY:一种无免疫原的CRISPR平台,用于暴露免疫能力模型中的隐藏转移调节器

Massimo Saini1, Francesc Castro-Giner1, Adriana Hotz2

  • 1Department of Biology, Institute of Molecular Health Sciences, Swiss Federal Institute of Technology (ETH) Zurich, 8093 Zurich, Switzerland.

Cell
|November 8, 2025
PubMed
概括

传统的CRISPR查在免疫能力模型中由于免疫反应而失败. 新的无免疫基因CRISPR平台StealTHY克服了这一问题, 能够发现癌症的弱点和转移调节剂.

关键词:
关于CRISPR的研究其他国家抗瘤免疫力癌症癌症免疫性人化小鼠发生转移来自患者的异种移植癌症的临床前模型

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