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Updated: Jan 12, 2026

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替代性开始的密码子选择塑造了线粒体功能和罕见的人类疾病

Jimmy Ly1, Matteo Di Bernardo1, Yi Fei Tao1

  • 1Whitehead Institute for Biomedical Research, Cambridge, MA, USA; Department of Biology, Massachusetts Institute of Technology, Cambridge, MA, USA.

Molecular cell
|November 8, 2025
PubMed
概括

替代性起始密码子选择产生了对细胞和线粒体功能至关重要的双局部蛋白质. 这个过程与罕见的遗传疾病有关,为疾病机制提供了新的见解.

关键词:
TRNT1 TRNT1 的时间其他替代的N端异型.另类翻译 替代翻译线粒体中的线粒体.蛋白质组的多样性 蛋白质组的多样性罕见的疾病 罕见的疾病开始 codon 的选择.开始翻译 开始翻译

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