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从进展到缓解:在慢性病中取得成功的新范式
Navdeep Tangri1, Brendon L Neuen2, David Z Cherney3
1Department of Internal Medicine, University of Manitoba, Winnipeg, Manitoba, Canada; Chronic Disease Innovation Centre, Seven Oaks Hospital, Winnipeg, Manitoba, Canada.
Kidney international
|November 8, 2025
概括
新的慢性病 (CKD) 治疗方法能够缓解,而不仅仅是减缓进展. 早期检测和组合疗法使脏健康的保护成为新的护理标准.
科学领域:
- 腎臟病學 (nephrology) 是一種醫學專業.
- 内部医学 内部医学
背景情况:
- 慢性病 (CKD) 管理传统上专注于减缓疾病进展.
- 最近的治疗进展为疾病缓解提供了潜力.
研究的目的:
- 要突出CKD治疗中的范式转变,从减缓进展到实现缓解.
- 强调早期检测和结合疗法对脏健康的重要性.
主要方法:
- 对涉及新型治疗剂的里程碑式临床试验的审查.
- 对持续估计膜过率 (eGFR) 保存和专尿正常化数据的分析.
- 缓解的定义基于eGFR斜率和白蛋白尿状态.
主要成果:
- -葡萄糖共运输体2抑制剂,矿物质皮质醇受体对抗剂和其他药物在糖尿病和球脏疾病中表现出有效性.
- 持续的eGFR保护和白蛋白尿的正常化是可以实现的目标.
- 通过早期检测和组合治疗,缓解越来越容易实现.
结论:
- 慢性病治疗应将重点从延缓进展转移到维持脏健康.
- 基于人群的查,风险分层和指南导向治疗至关重要.
- 在CKD中实现缓解应该成为标准的护理.
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