选择性胎儿生长限制类型II:IIb或非IIb
Ariane C Youssefzadeh1, Ramen H Chmait1
1Division of Maternal-Fetal Medicine, Department of Obstetrics and Gynecology, Keck School of Medicine, University of Southern California, Los Angeles, CA.
American journal of obstetrics & gynecology MFM
|November 8, 2025
概括
在单胞胎双胞胎中,选择性胎儿生长限制 (SFGR) 存在风险. 早期的SFGR II型,以前与糟糕的结果有关,可能会从分类 (IIa vs. IIb) 中受益,以改进预后和管理策略.
科学领域:
- 周围生理学 周围生理学
- 孕产妇和胎儿医学 孕产妇和胎儿医学
- 双胞胎怀孕研究 双胞胎怀孕研究
背景情况:
- 双胞胎共享一个胎盘,导致独特的风险.
- 选择性胎儿生长限制 (SFGR) 影响高达25%的这些怀孕由于胎盘和血管异常.
- 格拉塔科斯分类系统基于动脉多普勒检测结果 (I,II,III类型) 来分层SFGR风险.
研究的目的:
- 审查单双胞胎中早期的SFGR II型的管理挑战.
- 探索将II型SFGR分类为IIa型和IIb型的潜在好处.
- 提高预后准确度,指导这些高风险怀孕的管理决策.
主要方法:
- 对单胆双胞胎双胞胎中SFGR现有文献的综述.
- 分析格拉塔科斯分类系统及其预后影响.
- 对II型SFGR的当前和潜在管理策略的讨论.
主要成果:
- 第二种类型的SFGR与显著的围产期发病率和死亡率有关.
- 第二种类型的SFGR的临床过程是可变的,需要采取细微的方法.
- 将其分为IIa型和IIb型的分类可以提供更好的风险分层.
结论:
- 对第二种类型SFGR的最佳管理仍然存在争议,其中包括预期管理,带阻塞和激光光凝固等选项.
- 将第二种类型的SFGR分类可能会导致更个性化的治疗计划.
- 需要进一步的研究来验证IIa/IIb分类,以改善SFGR类型II怀孕的结果.
相关概念视频
Diabetes Mellitus: Type 2 and Gestational
4.3K
Type 2 diabetes, characterized by insulin resistance, arises when the insulin receptors on cells lose responsiveness to insulin, diminishing the cell's capacity to take up glucose, resulting in elevated blood glucose levels. To receive a diagnosis of Type 2 diabetes, a series of blood glucose tests are necessary to assess whether the blood glucose falls within normal parameters. If the result is out of the normal range, a patient may be diagnosed as prediabetic or diabetic, depending on the...
4.3K
Teratogenicity
3.9K
The ability of a drug to produce structural deformations and functional abnormalities in the developing embryo or the fetus is called teratogenicity, and the drug producing this effect is known as a teratogen. Teratogenic effects include stillbirth, miscarriage, intrauterine growth restriction, and neurocognitive delay. A teratogen may affect the embryo at different stages of development, which is important in determining the type and extent of the damage. During blastocyst formation, the early...
3.9K
Diabetes Mellitus: Overview and Type I Subtype
4.8K
Diabetes mellitus is a chronic metabolic disorder characterized by high blood glucose levels due to inadequate insulin production, insulin resistance, or both. The condition affects millions worldwide and can significantly impact their health and quality of life.
Type 1 diabetes is an autoimmune disease in which the immune system mistakenly attacks and destroys the insulin-producing beta cells in the pancreas. As a result, the body is unable to produce sufficient insulin, and individuals with...
Type 1 diabetes is an autoimmune disease in which the immune system mistakenly attacks and destroys the insulin-producing beta cells in the pancreas. As a result, the body is unable to produce sufficient insulin, and individuals with...
4.8K
Pathophysiology of Diabetes
3.1K
Diabetes mellitus is a chronic metabolic disorder characterized by hyperglycemia. The four categories of diabetes are type 1 diabetes, type 2 diabetes, other specific types of diabetes, and gestational diabetes.
Type 1 diabetes is characterized by autoimmune-mediated destruction of pancreatic β cells, with environmental factors potentially triggering this process in genetically susceptible individuals. Despite many not having a family history, certain genes increase susceptibility,...
Type 1 diabetes is characterized by autoimmune-mediated destruction of pancreatic β cells, with environmental factors potentially triggering this process in genetically susceptible individuals. Despite many not having a family history, certain genes increase susceptibility,...
3.1K
Meiosis II
206.6K
Meiosis II is the second and final stage of meiosis. It relies on the haploid cells produced during meiosis I, each of which contain only 23 chromosomes—one from each homologous initial pair. Importantly, each chromosome in these cells is composed of two joined copies, and when these cells enter meiosis II, the goal is to separate such sister chromatids using the same microtubule-based network employed in other division processes. The result of meiosis II is two haploid cells, each...
206.6K
Genomic Imprinting and Inheritance
36.8K
Diploid organisms inherit genetic material through chromosomes from both parents. Copies of the same gene are known as alleles. In most cases, both alleles are simultaneously expressed and allow various cellular processes to function optimally. If one of the alleles is missing or mutated, the expression of the other allele can compensate; however, this is not true for all genes.
The expression of some genes depends on which parent passed the gene to the offspring, through a phenomenon known as...
The expression of some genes depends on which parent passed the gene to the offspring, through a phenomenon known as...
36.8K


