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Updated: Jan 11, 2026

Overexpressing Long Noncoding RNAs Using Gene-activating CRISPR
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调节NLRP3与反意义寡核酸的拼接,以控制病理性炎症

Roni Klein1,2, Janset Onyuru3, Jessica L Centa1,4

  • 1Center for Genetic Diseases, Chicago Medical School, Rosalind Franklin University of Medicine and Science, North Chicago, IL 60064, United States.

Nucleic acids research
|November 8, 2025
PubMed
概括

科学家使用拼接切换反感性寡核酸 (ASO) 来控制NLRP3炎症体,这是炎症的关键因素. 这种方法通过向特定的NLRP3蛋白形式来减少有害的炎症,提供了潜在的新疗法.

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