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Updated: Jan 11, 2026

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对抗TNFα治疗的不充分反应与患有牛皮关节炎的患者的TNFR2-R多态变异功能获取相关

James K Sullivan1, Vandana Rai2, Jennifer Harvey2

  • 1Cleveland Clinic Lerner College of Medicine of Case Western Reserve School of Medicine, Cleveland, Ohio, USA.

Annals of the rheumatic diseases
|November 8, 2025
PubMed
概括

瘤坏死因子受体2 (TNFR2) 的特定遗传变异与牛皮关节炎患者对瘤坏死因子α抑制 (TNFi) 治疗的反应不佳有关. 这种TNFR2-R变体显示出独立于TNFα的增强的促炎活性,表明治疗失败的机制.

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