在炎症性肠病 (IBD-BOOST) 中治疗疲劳,疼痛和便失禁的数字认知行为自我管理计划:多中心,并行,随机对照试验
Rona Moss-Morris1, Christine Norton2, Ailsa Hart3
1Department of Psychology, Institute of Psychiatry, Psychology and Neuroscience, King's College London, London Bridge, London, UK.
IBD-BOOST数字自我管理工具并没有显著改善炎症性肠病 (IBD) 患者的生活质量. 然而,那些遵守干预措施的人显示出好处,这表明未来有针对性的方法的潜力.
科学领域:
- 胃肠道学和肝病学
- 数字健康干预措施 数字健康干预措施
- 患者自我管理
背景情况:
- 炎症性肠病 (IBD) 通常会导致衰弱的疲劳,疼痛和便急迫性/失禁.
- 需要有效的自我管理策略来改善IBD患者的生活质量.
研究的目的:
- 评估数字,交互式,辅导员支持的IBD-BOOST自我管理干预措施的有效性.
- 将IBD-BOOST与标准护理进行比较,以缓解IBD症状并提高患者的生活质量.
主要方法:
- 一个多中心,并行,随机对照试验在英国进行在线.
- 患有IBD和显著症状负担的参与者 (18岁以上) 被随机 (1:1) 分给IBD-BOOST或6个月的常规护理.
- 主要结局包括英国炎症肠病问卷 (UK-IBDQ) 和6个月症状缓解的全球评级.
主要成果:
- 在6个月后,IBD-BOOST和通常护理组之间在英国IBDQ得分或全球症状缓解评级中没有观察到统计学上显著的差异.
- 符合者平均因果效应分析表明,遵守IBD-BOOST的参与者报告了显著较低的UK-IBDQ得分 (p=0.016).
- 两组间的不良事件相似;IBD-BOOST组中发生了一种可能与治疗相关的严重不良事件 (睡眠障碍).
结论:
- 与常规护理相比,IBD-BOOST干预措施并没有显示出与疾病特定的生活质量或症状缓解的统计学上显著改善.
- 坚持IBD-BOOST计划似乎与患者报告的益处有关.
- 未来的研究应该专注于加强干预合规性的策略,并将计划定制为最有可能受益的个人.
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