在接受心脏手术的免疫能力强的患者中发生的简单疹病毒肺炎:病例系列
Doriana Lacalaprice1, Pietro Vitale2, Alessio Alleva3
1Section of Hygiene, Department of Life Sciences and Public Health, Catholic University of the Sacred Heart, Rome, Italy.
Journal of cardiothoracic and vascular anesthesia
|November 8, 2025
概括
简单疹病毒-1 (HSV-1) 肺炎在34.9%的心脏手术患者中被诊断出患有呼吸系统问题. 这种感染导致了长时间的重症监护室住院和高死亡率,特别是在紧急手术后.
科学领域:
- 传染性疾病 传染性疾病
- 心脏病学 心脏病学
- 关键护理医学 关键护理医学
背景情况:
- 没有已知的免疫缺陷的心脏手术患者可能会出现呼吸系统恶化.
- 简单疹病毒-1 (HSV-1) 肺炎是一种潜在的,经常被忽视的,术后并发症的原因.
研究的目的:
- 为了确定HSV-1肺炎的发病率,诊断方法和管理.
- 为了分析心脏外科手术患者患有HSV-1肺炎的结果.
主要方法:
- 成年患者进行心脏外科手术的回顾性观察病例系列.
- 诊断HSV-1肺炎所需的阳性定量HSV-1聚合酶链反应 (PCR) 在支气管洗 (BAL) 或支气管吸附液 (BAS) 样本 (>10,000副本/毫升) 患者有不明原因的呼吸系统恶化.
- 收集的数据包括基线,术前和术后的变量.
主要成果:
- 在34.9%的心脏手术患者中检测到HSV-1 (15/43).
- 在BAL/BAS中,病毒载量的中位数为3.21×106副本/毫升;诊断发生在手术后12天的中位数.
- 患者经历了长时间的重症监护病房停留 (中位数为54天),机械通风率高 (86.7%) 和急性呼吸困扰综合征 (73.3%),住院死亡率为66.7%.
结论:
- 在心脏外科手术患者的呼吸衰竭中,HSV-1肺炎是一个重要的发现.
- 观察到高死亡率,特别是在那些接受紧急手术的人群中.
- 需要进一步的研究来优化治疗,并了解HSV-1对患者结果的全部影响.
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