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Angle-closure glaucoma, or closed-angle glaucoma, is an eye condition where the iris bulges out and blocks the iridocorneal angle, resulting in a buildup of aqueous humor and increased intraocular pressure. Immediate medical attention is necessary due to the sudden onset of symptoms. The treatment for angle-closure glaucoma includes short-term and long-term approaches. Short-term treatment involves using eye drops like pilocarpine to lower intraocular pressure by increasing aqueous humor...
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In open-angle glaucoma, the iridocorneal angle remains open, but the trabecular meshwork becomes stiff, slowing down the outflow of aqueous humor. This causes a buildup of aqueous humor in the anterior chamber, leading to a sudden increase in intraocular pressure. The treatment for open-angle glaucoma focuses on reducing the elevated intraocular pressure by either decreasing the secretion of aqueous humor or increasing its outflow.
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机器学习预测 - 在眼睛质子疗法中以NTCP评估为基础的视线优化.

Daniel Björkman1,2, Antony Lomax1,2, Maria De Prado1

  • 1Center for Proton Therapy (CPT), Paul Scherrer Institute, Villigen, Switzerland.

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概括

这项研究引入了眼睛质子疗法 (OPT) 规划的自动化方法,优化眼睛的方向,以最大限度地减少辐射暴露和毒性风险. 在92%的病例中,自动化计划是可比或可取的,提高了治疗效率和安全性.

关键词:
自动化自动化自动化自动化眼内瘤 眼内瘤辐射疗法 辐射疗法治疗计划 治疗计划

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科学领域:

  • 医学物理 医学物理
  • 辐射瘤学 辐射瘤学
  • 计算生物学 计算生物学

背景情况:

  • 眼睛质子疗法 (OPT) 规划已经依赖于手动方法超过40年,使用系统,如EyePlan.
  • 目前的手动规划通过凝视定位点优化了眼睛的方向,但与毒性风险没有直接关联.
  • 这种手动方法是低效的,容易导致规划者偏见,并错过了自动化,毒性信息化的指导的机会.

研究的目的:

  • 开发一种计算效率高,用于OPT治疗规划的自动化方法.
  • 优化眼睛的方向,以最大限度地减少健康组织的暴露,并减少辐射引起的毒性.
  • 为临床医生提供直观,临床相关的信息,以改善治疗决策.

主要方法:

  • 使用了与机器学习 (ML) 凝视预测集成的内部治疗计划系统 (OCULARIS).
  • 采用量身定制的成本函数,快速识别最佳的眼睛定向,以节省健康组织.
  • 使用成本指标和正常组织并发症概率 (NTCP) 模型评估的自动化定向,经过经验丰富的医学物理学家的验证.

主要成果:

  • 在92%的案例中,自动化计划是可取的或与临床计划相似的 (25%被评为可取).
  • 在67%的病例中观察到可比的毒性水平.
  • 47%的自动化计划显示在一个NTCP中至少有1%的改善,而不会对其他NTCP产生负面影响.

结论:

  • 开发的方法为OPT规划提供了更为明智,高效和自动化的策略.
  • 为规划者提供直接信息,将眼睛定向与毒性风险联系起来.
  • 在92%的患者中,用于OPT的自动生成的眼睛定向显示了相似或更高的适用性.