美国成年人中UHR和骨矿物质密度之间的非线性关联:NHANES 2017-2018年
Han Wen1, Minfeng Zhou2, Huifang Niu3,4
1Hunan University of Medicine, The First People's Hospital of Pingjiang, 431 North Street, Chengguan Town, Pingjiang County, 414500, China. 1353356644@qq.com.
European journal of medical research
|November 8, 2025
概括
尿酸与高密度胆固醇的比率 (UHR) 显示了与骨矿物质密度 (BMD) 的非线性联系. 19的UHR是一个转折点,表明UHR可能是骨健康的生物标志物.
科学领域:
- 代谢健康和骨生理学.
- 发现了骨健康的生物标志物.
背景情况:
- 低骨矿物质密度 (BMD) 会增加骨质疏松症和骨折风险,特别是在老年人中.
- 血清尿酸 (UA) 和高密度脂蛋白胆固醇 (HDL-C) 是骨健康的潜在代谢决定因素.
- 尿酸与高密度胆固醇的比率 (UHR) 为骨健康提供了一个新的代谢视角.
研究的目的:
- 调查尿酸与高密度胆固醇 (HDL) 的比例 (UHR) 和大腿骨矿物质密度 (BMD) 之间的关联.
- 探索UHR和大腿部部BMD之间的潜在非线性关系.
- 根据身体质量指数 (BMI),年龄和性别,检查UHR-BMD关联中的子组变化.
主要方法:
- 利用了2017-2018年国家健康和营养检查调查 (NHANES) 的2178名参与者的数据.
- 计算UHR是血清UA与HDL-C的比率.
- 通过使用双能X射线吸收计 (DXA) 评估大腿部 BMD.
- 采用两部分线性回归模型来分析非线性关联,并根据BMI,性别和年龄进行分层分析.
主要成果:
- 确定了UHR-BMD关系中的一个显著的转折点,UHR=19.
- 在这个值以下,观察到UHR和大腿部BMD之间的积极关联 (β=0.0054,p=0.013).
- 在拐点以上,关联变为负,但没有统计学意义 (β=-0.0016,p=0.478).
- 在同变量调整 (β=0.0145,p=0.012) 后,这种关联在墨西哥裔美国人中仍然显著.
结论:
- 在UHR和大腿部部BMD之间存在非线性关联,在UHR=19.1的临界拐点.
- UHR可以作为评估骨健康的宝贵生物标志物,特别是在代谢风险人群中.
- 需要进一步的纵向研究来确认因果关系,并探索改善骨健康的UHR向干预措施.
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