2026年的BRENDA:一个全球核心生物数据资源,用于DSMZ数字多样性中的功能性酶和代谢数据
Julia Hauenstein1, Lisa Jeske1, Antje Jäde1
1Leibniz Institute DSMZ-German Collection of Microorganisms and Cell Cultures, Inhoffenstraße 7 B, 38124 Braunschweig, Germany.
Nucleic acids research
|November 9, 2025
概括
布伦达酶数据库现在具有用于语义搜索和数据集成的知识图,增强其作为核心生物数据资源的作用. 最近的更新改进了数据的可访问性和与其他生物信息平台的互操作性.
科学领域:
- 生物化学和生物信息学
- 酶学 是一种酶学.
- 数据科学数据科学数据科学
背景情况:
- BRENDA 是一个全面的酶和配体数据库.
- 它作为一个ELIXIR核心数据资源和全球核心生物数据资源.
- 最近的发展旨在加强数据集成和可访问性.
研究的目的:
- 详细介绍BRENDA数据库最近的进展情况.
- 突出新功能,促进数据集成和语义搜索.
- 为了展示BRENDA的扩展内容和改进的用户界面.
主要方法:
- 融入DSMZ数字多样性联盟.
- 开发一个原型的知识图表与公共的SPARQL终点.
- 扩大策划的路径集合,并增加交互式路径页面.
- 整合了DSMZCellDive数据和一个新的基因中心搜索界面.
主要成果:
- 目前,BRENDA 存储了大约 580 万个数据点,涵盖超过 112,000 个酶.
- 一个知识图可以根据FAIR原则进行语义搜索和数据集成.
- 该数据库包括195个新陈代谢地图,交互途径摘要和链接到人类细胞系.
- 一个新的以基因为中心的搜索接口改善了对酶特定数据的访问.
结论:
- 最近的BRENDA更新显著提高了其互操作性和分析能力.
- 这些新功能巩固了它作为生命科学研究的重要资源的地位.
- 数据库的进步支持数据集成和可重复使用,符合FAIR原则.
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