2026 年的 ProteomeXchange 联盟:使蛋白质组学数据公平
Eric W Deutsch1, Nuno Bandeira2,3,4, Yasset Perez-Riverol5
1Institute for Systems Biology, Seattle WA 98109, United States.
Nucleic acids research
|November 9, 2025
概括
保护体Xchange联盟标准化了基于质谱 (MS) 的蛋白质组学数据共享. 最近的发展表明,数据提交的速度加快,数据的重复使用增加,未来计划为控制访问数据和非MS方法.
科学领域:
- 蛋白质组学是指蛋白质组学.
- 生物信息学是一种生物信息学.
- 数据科学数据科学数据科学
背景情况:
- ProteomeXchange联盟成立的目的是为了在基于质谱 (MS) 的蛋白质组学中标准化开放数据实践.
- 六个全球数据库 (PRIDE,PeptideAtlas,MassIVE,jPOST,iProX,Panorama Public) 组成了这个联盟. 这些数据库包括:
研究的目的:
- 报告过去三年 ProteomeXchange 中的关键发展情况.
- 突出数据提交,标准化和数据再利用方面的进展.
主要方法:
- 分析来自ProteomeXchange会员数据库的数据提交统计数据.
- 对支持蛋白质组学标准倡议标准 (例如,通用频谱标识符,SDRF-蛋白质组学) 的改进进行审查.
- 评估数据再利用趋势和机器学习在蛋白质组学数据分析中的应用.
主要成果:
- 数据提交到ProteomeXchange的速度有所加速,在过去三年 (到2025年6月) 提交的64,330个数据集中,47%是数据.
- 加强对蛋白质学标准倡议标准的支持已经实施.
- 越来越多的数据重复使用是显而易见的,包括重新分析和新的机器学习应用.
结论:
- ProteomeXchange继续增长,促进了基于MS的蛋白质组学中的开放数据实践.
- 未来的努力将集中在对受控访问的人类蛋白质组学数据和非MS蛋白质组学方法的资源上.
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