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土地使用驱动一种空气传播的人类真菌病原体的耐药性

Hylke H Kortenbosch¹, Bo Briggeman^1,2, Francisca Reyes Marquez¹

¹Laboratory of Genetics, Wageningen University & Research, Wageningen 6700 AA, Gelderland, The Netherlands.

The ISME journal

|November 9, 2025

概括

空气中的菌 Aspergillus fumigatus 显示对抗真菌三醇的耐药性. 农业用地,特别是花和温室,与空气传播的A. fumigatus种群的抗真菌耐药性增加有关.

科学领域:

环境科学环境科学
菌类学菌类学是指菌类学.
公共卫生公共卫生

背景情况:

人类吸入Aspergillus fumigatus,这种菌会导致对三抗真菌药物耐药的感染.
环境来源和农业环境对A. fumigatus中抗醇耐药性的贡献尚未完全理解.
基因组方法难以将耐药分离物追溯到特定的环境来源.

研究的目的:

为了研究空气中的Aspergillus fumigatus中抗醇的空间分布和环境驱动因素.
量化荷兰A. fumigatus种群中抗醇耐药性的流行率.
为了确定农业用地使用与空气中的A. fumigatus.抗真菌耐药性之间的关联.

主要方法:

在荷兰各地使用公民科学方法进行了大规模的,公正的空气采样.
超过6万个A. fumigatus殖民地被选,以检测对临床三醇的耐药性.
空间建模将抗性数据与土地使用数据集成在一起,对耐药单独的样本进行了基因定型.

主要成果:

大约4%的选A. fumigatus殖民地表现出对临床三醇的耐药性.
农业用地,特别是花和温室,被发现可以预测空气中的A. fumigatus的抗真菌耐药性热点.
基因型鉴定揭示了耐药性单元型之间的利基差异化,其中一个单元型与农业用地使用密切相关.

结论:

农业实践,特别是涉及花球和温室的农业实践,大大促进了空气传播的A. fumigatus中抗真菌耐药性的流行.
将三醇耐药性与特定的土地用途联系起来,为制定减轻人类暴露的政策提供了关键信息.
类似的抗真菌耐药性的空间模式可能存在于与农业环境相关的其他真菌中.

关键词:

亚斯伯吉拉斯烟虫 (Aspergillus fumigatus) 是一种有毒的植物.抗菌药物反症 (AMR) 是一种空气采样采样空气采样公民科学是公民科学.风险暴露风险暴露风险暴露一个健康的健康.有三醇的三醇.

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