较好的心血管健康的好处 对于 Calcific 大动脉狭窄症 多基因风险评分分层分的多基因风险评分
Yuexin Zhu1,2,3, Qiuli Chen4,5,6, Bokang Qiao1,2,3
1Beijing Collaborative Innovation Center for Cardiovascular Disorders, MOE Key Laboratory of Remodeling-related Cardiovascular Disease, Beijing Anzhen Hospital, Capital Medical University, Beijing 100029, China.
Genomics, proteomics & bioinformatics
|November 9, 2025
概括
使用Life's Essential 8 (LE8) 改善心血管健康 (CVH) 可以降低状大动脉狭窄症 (CAVS) 风险,特别是在具有高遗传倾向的人群中. 优化CVH是预防的关键.
科学领域:
- 心脏病学 心脏病学
- 预防医学 预防医学
- 遗传学 是一个遗传学.
背景情况:
- 动脉狭窄 (CAVS) 的患病率正在随着全球老龄化而上升.
- 即使是轻微的CAVS也会增加死亡风险,需要采取预防策略.
研究的目的:
- 调查心血管健康 (CVH) 与CAVS.遗传风险之间的关联.
- 探索生命的基本8 (LE8) 评分,遗传风险和CAVS之间的相互作用.
主要方法:
- 分析了153312名参与者的数据.
- 评估生活必需品8 (LE8) 评分和遗传风险评分.
- 对CVH风险,遗传风险和年龄之间的相互作用的评估.
主要成果:
- 较高的LE8得分与降低CAVS风险有关 (HR/SD:0.72).
- 较高的遗传风险得分与增加的CAVS风险有关 (HR/SD: 1.63).
- 确定了CVH和CAVS遗传风险之间的显著添加相互作用,在高遗传风险和贫困CVH群体中观察到协同效应.
结论:
- 通过LE8优化CVH对于降低CAVS风险至关重要,无论遗传风险如何.
- 高遗传风险和低CVH协同扩大了CAVS风险.
- 早期和持续的CVH优化对于减轻CAVS至关重要,特别是在遗传敏感的个体中.
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