生涯职业和准职业接触有机溶剂和丸生殖细胞瘤风险:一项法国病例对照研究-TESTIS
Margot Guth1, Marie Lefevre1, Astrid Coste2,3
1UMRESTTE, UMR T 9405, IFSTTAR, Lyon 1 University, Lyon University, Eiffel University, Lyon, France.
International journal of epidemiology
|November 9, 2025
概括
成年后的职业溶剂暴露,特别是三乙烯和石油基溶剂,与丸生殖细胞瘤 (TGCT) 的风险增加有关. 终身暴露没有显著关联,但青少年暴露也可能起作用.
科学领域:
- 在瘤学瘤学.
- 环境健康 环境健康
- 流行病学 流行病学
背景情况:
- 丸生殖细胞瘤 (TGCT) 的发病率正在上升,但其原因仍然不清楚.
- 一个两阶段的发育假设表明子宫内变化随后的恶性转变.
- 本研究调查了职业溶剂暴露与TGCT风险之间的联系.
研究的目的:
- 检查累计终身职业和副职业溶剂暴露与TGCT风险之间的关联.
- 评估不同生命阶段 (胎儿,儿童,青春期,成年期) 暴露于溶剂对TGCT发育的影响.
- 为了确定与增加TGCT风险相关的特定溶剂.
主要方法:
- 一项法国多中心病例控制研究 (TESTIS) 涉及454例病例和670例对照.
- 从参与者及其母亲那里收集的职业史数据,使用Matgéné职业暴露矩阵进行溶剂暴露评估.
- 条件后勤回归模型用于估计TGCT风险的几率比率 (OR) 和95%置信区间 (CI).
主要成果:
- 累积终身溶剂暴露与TGCT风险没有显著关联 (OR=1.03).
- 成年人对特定溶剂的职业暴露与TGCT风险增加有关:三乙烯 (OR=3.09),燃料/石油溶剂 (OR=1.91),柴油/煤油/燃料油 (OR=2.26) 和/ (OR=1.66).
- 在青春期暴露于溶剂表明与TGCT风险的积极关联 (OR=1.77).
结论:
- 累计终身暴露于溶剂似乎不是TGCT风险的主要因素.
- 成年期间的职业溶剂暴露与TGCT的风险增加有关.
- 在青少年时期通过间接暴露于溶剂来促进TGCT发育的潜在可能性需要进一步调查.
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