人类乳头瘤病毒疫苗接种对早产率的影响
Tiina Koivisto1,2, Ilkka Kalliala3, Tiina Eriksson4
1Faculty of Medicine and Health Technology, Tampere University, Tampere, Finland.
European journal of public health
|November 9, 2025
概括
预防性人类乳头瘤病毒 (HPV) 疫苗接种可能会降低早产率. 这项研究发现,HPV疫苗接种和早产婴儿数量减少之间存在保护性关联,这表明有公共卫生益处.
科学领域:
- 产科和妇科 产科和妇科
- 公共卫生 公共卫生
- 疫苗学 疫苗学 疫苗学
背景情况:
- 宫癌前病变,通常是由人类乳头瘤病毒 (HPV) 感染引起的,需要像化这样的治疗,这是早产的一个重要原因.
- 预防性HPV疫苗接种可以预防这些子宫病变,从而减少对除性治疗的需求,并可能降低早产率.
研究的目的:
- 评估预防性HPV疫苗接种与早产发病率之间的关联.
- 为了比较HPV疫苗接种妇女与未接种妇女的早产率.
主要方法:
- 一项使用全国芬兰登记数据的队列研究,将出生和接种疫苗记录联系起来.
- 包括在1990-1993年间出生的HPV接种疫苗,乙型肝炎病毒接种疫苗和未接种疫苗的妇女.
- 后勤回归分析以评估HPV疫苗接种与早产之间的关联,分为早产和晚产.
主要成果:
- 在28岁时,4.1%的HPV疫苗接种原产妇和5.2%的未接种疫苗的原产妇经历过早产.
- 接种HPV疫苗显示出与早产 (几率比:0.79;95% CI:0.59-1.04),具有边界统计学意义的保护性关联.
- 在这两组中,大多数早产儿都被归类为晚期早产.
结论:
- 预防性HPV疫苗接种可能会降低早产的发生率.
- 通过HPV疫苗接种来减少早产,可以显著减少对昂贵的产后护理的需求,并减轻长期发病率.
- 广泛采用HPV疫苗接种有望改善母亲和婴儿健康结果.
相关概念视频
Vaccinations
51.1K
Overview
51.1K
Cancer Vaccines
917
Cancer treatment vaccines are a rapidly evolving field that offers a promising approach to immunotherapy. Unlike traditional vaccines that prevent diseases, cancer treatment vaccines are designed to treat existing cancers by stimulating the immune system to recognize and attack cancer cells.
Cancer vaccines come in two categories: preventive (prophylactic) and treatment (active). Preventive vaccines, such as the Human Papillomavirus (HPV) vaccine, protect against viruses that cause certain...
Cancer vaccines come in two categories: preventive (prophylactic) and treatment (active). Preventive vaccines, such as the Human Papillomavirus (HPV) vaccine, protect against viruses that cause certain...
917
Teratogenicity
3.9K
The ability of a drug to produce structural deformations and functional abnormalities in the developing embryo or the fetus is called teratogenicity, and the drug producing this effect is known as a teratogen. Teratogenic effects include stillbirth, miscarriage, intrauterine growth restriction, and neurocognitive delay. A teratogen may affect the embryo at different stages of development, which is important in determining the type and extent of the damage. During blastocyst formation, the early...
3.9K
Birth Control Methods
5.8K
Vasectomy is a surgical form of male sterilization that involves severing and sealing the vasa deferentia, preventing sperm from mixing with semen during ejaculation. Because a vasectomy does not impact the testes' ability to produce testosterone, hormone levels, libido, and sexual function generally remain unchanged. While vasectomy is highly effective in preventing pregnancy, with a success rate near 99.85%, rare cases of recanalization (spontaneous reconnection) can occur. Although...
5.8K
Prevalence and Incidence
1.4K
In statistical epidemiology and health sciences, two essential metrics—prevalence and incidence—are fundamental for understanding disease dynamics within a population. These measures enable public health officials, epidemiologists, and researchers to assess the burden of diseases, allocate resources effectively, and design impactful public health policies and interventions.
Prevalence indicates the proportion of individuals in a population who have a specific disease or health...
Prevalence indicates the proportion of individuals in a population who have a specific disease or health...
1.4K
Factors Affecting the Risk of Infection
13.2K
The hosts' susceptibility to infection depends on several factors. The integrity of the skin and mucous membranes helps protect the body against microbial attacks. When the skin is altered, the chance of infection, limb loss, and even death increases.
The integrity and count of the white blood cells help the body resist pathogens and fight infection. When impaired, it reduces the body's resistance to pathogens. The acidic pH levels of the gastrointestinal, genitourinary tracts, and skin...
The integrity and count of the white blood cells help the body resist pathogens and fight infection. When impaired, it reduces the body's resistance to pathogens. The acidic pH levels of the gastrointestinal, genitourinary tracts, and skin...
13.2K


