膜症在心房动:在英国生物银行研究中的不良结果的风险因素
Hong-Ju Kim1,2, Pil-Sung Yang1, Hanjin Park1
1Division of Cardiology, Department of Internal Medicine, Severance Cardiovascular Hospital, Yonsei University College of Medicine, 50-1 Yonsei-ro, Seodaemun-gu, Seoul 03722, Republic of Korea.
概括
肉症是一种肌肉损失的情况,与心房动 (AF) 患者的恶化结果有关. 这项研究发现,在患有AF的人群中,肉症增加了死亡和严重出血的风险.
科学领域:
- 心脏病学 心脏病学
- 老年病的医生 老年病的医生
- 代谢障碍 代谢障碍 代谢障碍
背景情况:
- 由肌肉质量和功能的减少来定义的sarcopenia在心血管疾病中越来越多地被认可.
- 在心房动 (AF) 中的预后意义尚未得到充分确立.
- 了解这种关联对于管理AF患者至关重要.
研究的目的:
- 调查被诊断患有心房动的个体中缩症和不良临床结果之间的关联.
- 评估萨尔科佩尼亚对AF患者死亡率,严重出血,血栓栓塞事件和心力衰竭住院治疗的影响.
主要方法:
- 一项回顾性队列研究,利用英国生物库数据从5144名AF患者 (2006-2010) 的数据.
- 根据欧洲老年肉病工作组2 (EWGSOP2) 标准 (低肌肉强度/质量) 进行的肉病诊断.
- 倾向性得分权重被用于调整基线差异;分析的结果包括死亡率,出血,血栓栓塞和心力衰竭的复合.
主要成果:
- 16.7%的AF患者表现出肉症.
- 萨科佩尼亚与初级复合结局 (aHR 1.30) 的更高发病率显著相关.
- 风险增加主要是由全因死亡率 (aHR 1.44) 和严重出血 (aHR 1.34) 驱动的.
结论:
- 膜症是心房动患者不良临床结果的独立预测因子.
- 这些发现突出显示,在患有肉症和AF的个体中,死亡率和出血的风险增加.
- 查肉可能会改善风险分层和患者管理,特别是那些服用抗凝药的人.
相关概念视频
01:29Cardiomyopathy III: Hypertrophic Cardiomyopathy
Hypertrophic cardiomyopathy, or HCM, is an autosomal dominant genetic disorder characterized by asymmetric left ventricular hypertrophy without ventricular dilation. It is more common in men and is typically diagnosed in young, athletic adults.EtiologyHCM is primarily genetic and is caused by mutations in genes encoding sarcomeric proteins. Researchers have identified over 1400 mutations across at least 11 different genes. Among these, the most frequently occurring mutations are found in the...
01:29Cardiomyopathy IV: Restrictive Cardiomyopathy
Restrictive cardiomyopathy (RCM) is a rare heart muscle disease characterized by impaired ventricular filling due to stiffened ventricular walls, leading to significant diastolic dysfunction.EtiologyRestrictive cardiomyopathy can arise from both inherited and acquired diseases, many of which are systemic. It is categorized into four main types: infiltrative, storage, non-infiltrative, and endomyocardial diseases.Infiltrative diseases, such as amyloidosis, lead to RCM by depositing amyloid...