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相关概念视频

Protein Organization01:24

Protein Organization

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Proteins are polymers of amino acid residues. They are versatile and responsible for different cellular functions, including DNA replication, molecular transport, catalysis, and structural support. Proteins have a hierarchical structure comprising at least three levels of organization: primary, secondary, and tertiary structure. Some large proteins have a quaternary structure where individual protein subunits are linked together.
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Groups of proteins may form a complex where each protein in this complex has a different role in the overall execution of the complex’s function. Often some of the proteins in the complex can be replaced by a closely related variant to give a complex that contains many of the same components yet is functionally distinct.
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Proteins are one of the most abundant organic molecules in living systems and have the most diverse range of functions of all macromolecules. Proteins may be structural, regulatory, contractile, or protective. They may serve in transport, storage, or membranes; or they may be toxins or enzymes. Their structures, like their functions, vary greatly. They are all, however, amino acid polymers arranged in a linear sequence.
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Physical models representing molecular architectures of chemical compounds play essential roles in understanding chemistry. The use of molecular models makes it easier to visualize the structures and shapes of atoms and molecules.
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相关实验视频

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RCSB蛋白质数据库:与实验结构和计算结构模型一起提供整合性结构.

Brinda Vallat1,2, Yana Rose3, Dennis W Piehl1

  • 1Research Collaboratory for Structural Bioinformatics Protein Data Bank and the Institute for Quantitative Biomedicine, Rutgers, The State University of New Jersey, Piscataway, NJ 08854, United States.

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概括
此摘要是机器生成的。

蛋白质数据库现在将整合/混合方法 (IHM) 结构与实验数据一起归档. RCSB.org增强了对这些和计算结构模型的访问,以实现更广泛的科学发现.

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科学领域:

  • 结构生物学 结构生物学
  • 生物信息学是一种生物信息学.

背景情况:

  • 蛋白质数据库 (PDB) 存档经过实验确定的大分子结构.
  • 全球蛋白质数据银行 (wwwPDB) 管理PDB,RCSB PDB作为美国数据中心.
  • RCSB.org提供了超过24万个实验结构和超过100万个计算结构模型 (CSM) 的访问权限.

研究的目的:

  • 描述PDB-IHM系统的集成,用于存档集成/混合方法 (IHM) 结构.
  • 详细说明PDB-IHM与PDB的统一,以便在单一方法的实验结构旁边进行存档.
  • 突出RCSB.org在访问和分析各种结构数据方面的扩展能力.

主要方法:

  • 由wwPDB联盟开发的PDB-IHM系统.
  • 将PDB-IHM数据与PDB的主要档案统一.
  • 加强RCSB.org以支持整合性结构,实验结构和CSM.

主要成果:

  • 通过结合多种实验和计算技术来确定的整合结构现在被归档在PDB中.
  • RCSB.org促进了对这些整合性结构的简化访问.
  • 扩展了RCSB.org功能,可以发现,分析和可视化集成的结构数据.

结论:

  • 将PDB-IHM与PDB统一,提高了结构数据的全面性.
  • 现在,RCSB.org提供了一个统一的平台,可以访问各种宏分子结构数据.
  • 这些进展促进了结构生物学中的更广泛的科学探索和发现.