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Updated: Jan 11, 2026

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HI-FEVER:一个Nextflow管道,用于高吞吐量发现和注释内源性病毒元素

Laura Muñoz-Baena¹, Emma F Harding¹, Jose Gabriel Nino Barreat^1,2

¹Department of Biology, University of Oxford, Oxford, OX1 3EL, United Kingdom.

Bioinformatics (Oxford, England)

|November 9, 2025

概括

HI-FEVER是一个新的Nextflow管道,简化了在真核生物基因组中发现内源性病毒元素 (EVE) 的过程. 该工具提高了计算效率,并为进化见解提供了详细的注释.

科学领域:

基因组学就是基因组学.
生物信息学是一种生物信息学.
进化生物学进化生物学

背景情况:

内源性病毒元素 (EVE) 是古代病毒感染的遗留物,集成到宿主基因组中.
检测EVE对于理解病毒与宿主共同进化至关重要,但它也带来了重大的计算和生物挑战.

研究的目的:

推出HI-FEVER,一个用户友好的Nextflow管道,旨在在真核生物基因组中高效地发现EVE.
为研究人员提供一个可定制和可扩展的工具来分析EVE及其进化影响.

主要方法:

开发一个名为HI-FEVER的Nextflow管道.
实现并行化和定制功能,以提高计算效率.
与集装箱技术 (Pixi,Conda,Apptainer,Docker) 的集成,以实现广泛的兼容性.

主要成果:

HI-FEVER能够在真核宿主基因组中发现EVE.
该管道提供了对发现的EVE的全面分析和详细注释.
HI-FEVER 展示了在各种计算平台上处理大型数据集的可扩展性.

结论:

HI-FEVER解决了EVE检测的挑战,为进化研究提供了宝贵的资源.
该管道的用户友好,效率和可扩展性使其可供广泛的研究人员使用.
HI-FEVER有助于更深入地了解病毒与宿主之间的进化相互作用.

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