RM2Target v2.0:一种更新的数据库,用于编写,除和读取RNA修改的目标基因
Xiaoqiong Bao1, Qi Jiang1, Weixuan Chen1
1School of Life Sciences, State Key Laboratory of Oncology in South China, Cancer Center, Collaborative Innovation Center for Cancer Medicine, Sun Yat-sen University, Guangzhou 510060, China.
Nucleic acids research
|November 9, 2025
概括
扩展的RM2Target v2.0数据库现在将数以百万计的RNA修饰蛋白 (写入器,擦除器和读取器) 与20种物种的目标基因联系起来. 这个资源有助于研究RNA表观遗传学和疾病联系.
科学领域:
- 分子生物学分子生物学
- 基因组学就是基因组学.
- 生物信息学是一种生物信息学.
背景情况:
- 了解RNA修饰蛋白 (WER) 与目标基因的关联是RNA修饰机制的关键.
- 此前,RM2Target数据库是作为人类和小鼠的WER-target关联资源而建立的.
- 越来越多的研究需要扩大数据库,涵盖新的修改和非模型物种.
研究的目的:
- 介绍RM2Target v2.0,一个更新和显著扩展的RNA修饰蛋白-基因关联的数据库.
- 增强数据覆盖,策划和注释,为RNA表转录学提供全面的资源.
主要方法:
- 收集和管理WER目标协会的数据.
- 扩展包括18种RNA修饰类型,273种WER蛋白,973种细胞系/组织以及20种物种.
- 整合广泛的目标基因注释,包括基因信息,修饰,相互作用和疾病联系.
主要成果:
- RM2Target v2.0 包含 4,400,616 个 WER 目标协会.
- 该数据库涵盖了18种RNA修饰类型和20种物种,并提供了全面的注释.
- 与之前的版本相比,更新版本显著增加了数据范围和细节.
结论:
- RM2Target v2.0 是RNA表写体调节研究的基础资源.
- 它可以探索修饰交叉交谈,分子机制和疾病关联.
- 该数据库促进了RNA表观遗传学的基础科学和翻译应用.
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