在接受Fingolimod治疗多发性硬化症的患者中发现了视网膜动脉瘤变化的新发现
Feliciana Menna1, Lucilla Barbano2, Carmen Dell'Aquila2
1Department of Medical-Surgical Sciences and Biotechnologies, U.O.C. Ophthalmology, Sapienza University of Rome, Via Firenze 1, 04019, Terracina, Italy. feliciana.menna@gmail.com.
Neurology and therapy
|November 9, 2025
概括
芬戈利莫德治疗可能会导致多发性硬化症患者的单侧视网膜动脉瘤. 在停止服用fingolimod后,这些血管变化可能会逆转,因此需要临床警.
科学领域:
- 眼科医生 眼科 眼科
- 神经学 神经学
- 药理学 药理学是指药理学的学科.
背景情况:
- 芬戈利莫德 (Gilenya®) 是一种治疗复发性复发性多发性硬化症 (RRMS) 的口服免疫调节剂.
- 新出现的证据表明,fingolimod可能与视网膜血管并发症有关.
- 这项研究调查了fingolimod治疗患者视网膜动脉瘤变化的新证据.
研究的目的:
- 在接受fingolimod治疗的患者中描述视网膜动脉瘤变化.
- 探索这些变化的潜在机制和临床影响.
- 评估fingolimod相关的视网膜变化的可逆性.
主要方法:
- 一个由五名fingolimod治疗和视网膜动脉瘤患者组成的病例系列.
- 多式成像,包括OCT血管造影,用于分析.
- 结果包括视觉敏度和视网膜厚度的变化.
主要成果:
- 观察到fingolimod和单边视网膜动脉瘤之间的潜在关联.
- 建议的机制包括内皮功能障碍和改变的血管透性.
- 视网膜动脉瘤变化在停止使用芬戈利莫德后回归.
结论:
- 芬戈利莫德可能会导致单边视网膜动脉瘤血管变化.
- 临床医生应监测潜在的视网膜并发症.
- 需要进一步的研究来了解机制和长期风险.
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