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Updated: Jan 11, 2026

Quantifying Antibody-Dependent Cellular Cytotoxicity in a Tumor Spheroid Model: Application for Drug Discovery
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抗体药物结合物的心脏毒性作用与ERBB2-阳性晚期乳腺癌的标准化疗:系统性审查和元分析

Lakshya Seth1, Aditya Bhave2, Sai Kollapaneni2

  • 1Department of Internal Medicine, University of Texas Southwestern Medical Center, Dallas.

JAMA network open
|November 9, 2025
PubMed
概括

在ERBB2阳性乳腺癌患者中,trastuzumab emtansine显示了最低的心脏毒性 (LVEF降低). 其他疗法,如trastuzumab deruxtecan具有类似的,更高的比率,表明需要进一步研究.

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