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从社会隔离到肉症:异质的社会隔离模式和炎症调解
Sicheng Li1,2, Lingxiao He1,2, Ya Fang1,2
1Key Laboratory of Health Technology Assessment of Fujian Province, School of Public Health, Xiamen University, Xiamen, China.
概括
在老年人中,社会隔离增加了肉症的风险,系统性炎症起到了部分作用. 加强家庭关系可能有助于预防肉症.
科学领域:
- 老年学与公共卫生
- 老龄化的流行病学.
- 萨尔科佩尼亚研究研究
背景情况:
- 社会隔离与肉症 (sarcopenia) 之间的关系,这是一种以肌肉损失为特征的老年综合征,尚未完全理解.
- 了解这种联系对于开发针对老龄化人口的有针对性的干预措施至关重要.
研究的目的:
- 调查45岁以上的中国成年人中,社会孤立与皮病之间的关联.
- 探索系统性炎症在这种关系中的潜在调解作用.
主要方法:
- 利用来自中国健康与退休长度研究 (2011-2015年) 的数据,共计7,059名参与者.
- 根据"2019年亚洲肉病工作组"标准定义了肉病.
- 采用隐性类分析 (LCA) 进行社会隔离模式和后勤回归进行风险评估,通过反向概率权重控制偏差,并检查系统性炎症的调解.
主要成果:
- 社会上孤立的个体在4年内表现出明显更高的患上萨尔科佩尼亚的风险 (OR: 1.34,95%CI: 1.01,1.76).
- 潜阶级分析发现了三种社会隔离模式;单身生活和未婚生活与增加的肉症风险有关.
- 系统性炎症部分介导了社会隔离和肉症之间的联系,占总影响的4.95%.
结论:
- 社会隔离是中老年和老年中国成年人中 Sarcopenia 的重要危险因素.
- 系统性炎症部分调解了这种关联,突出了它在病理生理学中的作用.
- 专注于加强社会联系,特别是家庭关系的干预措施,可能有效地预防或延迟肉症.
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