甲状腺疾病中的状况和补充:对当前证据的叙述性综述
Ye Htut Linn1, Sohail Aziz2, Shiueh Lian Mok1
1Department of Pharmacology, Faculty of Medicine, MAHSA University, Jalan SP 2, Bandar Saujana Putra, Jenjarom, Selangor 42610, Malaysia.
概括
补充剂对像Graves这样的自身免疫性甲状腺疾病显示出有前途.
科学领域:
- 内分泌学和营养科学 营养科学
- 研究微量元素在人类健康中的作用.
- 专注于甲状腺功能和自身免疫性疾病.
背景情况:
- (Se) 是一种重要的微量元素,对甲状腺激素代谢和抗氧化功能至关重要.
- 甲状腺缺乏与各种甲状腺疾病的发展和进展有关,特别是自身免疫性疾病.
- 目前关于甲状腺疾病中的Se状态和补充剂的证据需要全面审查.
研究的目的:
- 审查和综合目前关于状态和补充在各种甲状腺疾病的证据.
- 评估补充剂在治疗自身免疫性甲状腺疾病中的有效性.
- 识别知识缺口和未来研究领域.
主要方法:
- 现有科学文献的叙述性审查.
- 对检查甲状腺疾病患者的水平和补充结果的研究分析.
- 综合与特定甲状腺疾病相关的发现,包括格雷夫斯病,自身免疫性甲状腺炎等.
主要成果:
- 缺乏与自身免疫性甲状腺疾病 (AITD) 的风险和严重程度增加有关.
- 补充显示在格雷夫斯病 (GD),格雷夫斯轨道病 (GO) 和自身免疫性甲状腺炎 (AIT),包括哈希莫托甲状腺炎 (HT),通过减少自身抗体和炎症的潜在益处.
- 证据表明对甲状腺功能低下,与怀孕有关的甲状腺功能障碍,,甲状腺癌的影响是不一致的. 在某些情况下,生活质量可能会改善.
- 过度摄入可以导致毒性 (毒症).
结论:
- 补充剂可能提供治疗益处,特别是对于自身免疫性甲状腺疾病.
- 需要进一步进行高质量的随机对照试验,以确定各种甲状腺疾病的最佳剂量,形式和持续时间.
- 考虑基线状态和地理因素的个性化方法很重要.
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