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空气污染和肺癌:一个全面的审查

Valentin Héluain¹, Laurent Molinier², Julien Mazières¹

¹Department of Pulmonology, Toulouse University Hospital, France.

Journal of epidemiology and population health

|November 9, 2025

概括

空气污染是已知的致癌物质,与肺癌有关,导致全球14%的病例. 减少空气污染对公共卫生和应对气候变化至关重要.

科学领域:

环境健康环境健康
在瘤学瘤学.
流行病学流行病学

背景情况:

自2013年以来,空气污染被国际癌症研究机构 (IARC) 认定为致癌物.
流行病学研究将污染环境与肺癌死亡率的增加联系起来.
空气污染是全球第二大导致过早死亡的原因,约占肺癌的14%.

研究的目的:

突出空气污染的致癌潜力,特别是细颗粒物 (PM2.5).
阐明病理生理机制,将PM2.5暴露与特定癌症类型联系起来,包括具有表皮生长因子受体 (EGFR) 突变的癌症类型.
强调肺癌研究人员和临床医生之间合作努力的必要性,以减轻空气污染.

主要方法:

国际主要流行病学研究的综述.
分析最近关于细颗粒物 (PM2.5) 与癌症之间的病理生理联系的发现.
评估空气污染在肺癌发展中的作用,特别是在EGFR突变癌症中.

主要成果:

证实空气污染是肺癌的重要危险因素.
确定细颗粒 (PM2.5) 是一个主要的致癌物质.
关于参与空气污染引起的肺癌的分子途径 (例如EGFR突变) 的新兴理解.

结论:

肺癌研究界和临床科学家迫切需要解决大气污染源的问题.
公共卫生至关重要,以减少空气污染暴露.
需要将减少空气污染的战略与减缓气候变化的努力相结合.

关键词:

空气污染大气污染微粒微粒的细微粒子肺癌是一种肺癌.非吸烟者肺癌的研究在PM2.5中,PM2.5是最常见的.

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