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氨酸通过调节氧化应激和炎症来缓解腹腔大动脉动脉瘤,防止VSMC亡

Jing-Yu Li¹, Jing Li², Rui-Kang Guo²

¹Department of Cardiovascular Surgery, the Second Xiangya Hospital, Central South University, Changsha, China.

International immunopharmacology

|November 9, 2025

概括

氨酸 (HG) 通过激活AKT/mTOR通路和抑制NF-κB/PTGS2轴,为腹腔大动脉动脉瘤 (AAA) 显示治疗潜力,从而提供血管保护. 这种天然化合物表现出抗亡和抗炎作用,支持其在AAA治疗中的使用.

科学领域:

血管生物学和药理学
自然产品化学自然产品化学
分子医学是分子医学.

背景情况:

腹腔大动脉瘤 (AAA) 是一种血管疾病,其特征是VSMC亡,ECM降解和炎症,目前没有药理治疗方法.
研究了AAA中天然类化合物氨酸 (HG) 的治疗潜力和分子机制.

研究的目的:

评估胺 (HG) 在治疗腹腔大动脉瘤 (AAA) 的疗效.
阐明HG对AAA治疗作用的分子机制,重点关注VSMC亡,炎症和信号通路.

主要方法:

使用了体外VSMC模型 (H2O2和LPS诱导) 和体内弹性酶诱导的AAA小鼠模型.
采用网络药理学,分子对接,动力学模拟,CETSA,Western blot,RT-qPCR和免疫组织化学来识别目标和途径.
研究了HG.对AKT/mTOR和NF-κB/PTGS2信号轴的调制.

主要成果:

HG改善了VSMC活力,减少了细胞亡和ROS,并保留了收缩标志物.
在体内,HG减少了大动脉扩张,弹性质降解,以及亡和矩阵金属蛋白酶的标志物.
HG激活了AKT/mTOR通路并抑制了NF-κB/PTGS2轴,显示出抗炎和抗亡作用.

结论:

氨酸 (HG) 通过激活AKT/mTOR和抑制NF-κB/PTGS2.2来减弱AAA的进展.
HG通过抗亡和抗炎机制提供血管保护.
HG是一种有前途的多目标天然化合物,用于AAA治疗开发.

关键词:

大动脉动脉瘤是一个大动脉动脉瘤.细胞灭亡 (apoptosis) 是一种死亡的过程.原胺是一种原胺.炎症炎症是一种炎症.这就是ROSOS ROS.

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