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动态ALFF和动态Reho在双相情感障碍中:基因联系和诊断和治疗的预测价值
Chunguo Zhang1, Leyi Zhang2, Jiaquan Liang1
1Department of Psychiatry, The Third People's Hospital of Foshan, Foshan, Guangdong 528000, China.
Asian journal of psychiatry
|November 9, 2025
概括
通过dALFF和dReHo测量的动态大脑活动变化,可以作为双相情感障碍 (BD) 的神经成像标志物. 这些发现通过神经成像-转录组关联,为BD病理生理学提供了分子洞察力.
科学领域:
- 神经科学是一个神经科学.
- 精神病学是一个精神病学.
- 遗传学 遗传学 是一个
背景情况:
- 双极性障碍 (BD) 在休息状态的大脑活动和药物反应中呈现不明确的变化.
- 动态局部大脑活动指标 (dALFF和dReHo) 需要在BD中进一步调查.
研究的目的:
- 为了研究双相情感障碍中动态局部大脑活动.
- 评估低频波动动态幅度 (dALFF) 和动态区域均性 (dReHo) 的区分能力.
- 探索 BD 中动态大脑活动的转录组相关性.
主要方法:
- 77名BD患者和83名健康对照 (HC) 的休息状态fMRI数据.
- 计算动态局部指标 (dALFF和dReHo) 来量化大脑活动的变化.
- 支持向量机 (SVM) 模型用于组分类和治疗反应预测;使用艾伦人类大脑图谱基因表达数据评估的神经成像-转录组学关联.
主要成果:
- 与HC相比,BD患者在特定的大脑区域显示dReHo和dALFF降低.
- 药物治疗后没有观察到动态大脑活动的显著变化.
- SVM模型显示了中度的区分性表现 (AUC_dALFF = 0.83;AUC_dReHo = 0.71).
- 转录组分析确定了与dALFF和dReHo相关的基因组,丰富了突触和免疫通路.
结论:
- 改变的dALFF和dReHo模式可以作为双相情感障碍的神经成像标记,表明动态大脑活动受到干扰.
- 神经成像-转录组关联为BD病理生理学提供了分子洞察力.
- 由于样本大小和随访限制,研究结果需要谨慎解释.
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