在不可切割的腹膜间皮瘤中,真实世界的免疫疗法结果:法国的经验
Cristina Smolenschi1, Alice Boileve2, Pauline Vaflard3
1Medical Oncology Department, Gustave Roussy, Villejuif,France; Drug Development Department, Gustave Roussy, Villejuif, France.
European journal of cancer (Oxford, England : 1990)
|November 9, 2025
概括
免疫检查点抑制剂 (ICI) 在治疗不可手术的腹膜间皮质瘤方面显示出好处. 这项实际的欧洲研究证实了ICI作为这种罕见癌症的可行治疗选择.
科学领域:
- 在瘤学瘤学.
- 免疫治疗是一种免疫疗法.
- 间皮瘤研究 间皮瘤研究
背景情况:
- 腹膜间皮瘤是罕见的,可切除的病例需要手术和化疗.
- 无法手术的疾病缺乏标准的二线治疗.
- 瘤微环境表明对免疫检查点抑制剂 (ICI) 的潜在敏感性.
研究的目的:
- 评估ICI在患有不可手术的腹膜间皮瘤患者的疗效和安全性.
- 在这个患者队列中评估无进展生存 (PFS) 和整体生存 (OS).
主要方法:
- 在法国,在2017-2024年期间,对22名无法手术的腹膜间皮瘤患者进行了回顾性分析,这些患者接受了ICI治疗.
- 主要终点:PFS和OS.
- 治疗包括使用或不使用抗血管原剂的免疫疗法.
主要成果:
- 中位数的PFS为10.22个月,中位数的OS为16.8个月.
- 在可评估患者中,客观应答率为30%.
- 疾病控制率在6个月后为55%,在12个月后为41%,有可控的毒性 (3名患者有3级).
结论:
- 在这个欧洲现实世界队列中,基于ICI的治疗证明了益处.
- 应考虑ICI作为不可手术的腹膜间皮质瘤的有价值的治疗选择.
相关概念视频
01:27Tumor Immunotherapy
1.7K
Immunotherapy is a treatment that boosts or manipulates the immune system to fight diseases, including cancer. For instance, by stimulating an immune response through vaccinations against viruses that cause cancers, like hepatitis B virus and human papillomavirus, these diseases can be prevented. Nonetheless, some cancer cells can avoid the immune system due to their rapid mutation and division. The immune response to many cancers involves three phases: elimination, equilibrium, and escape.
1.7K
02:56Treatment Resistant Cancers
3.7K
Cancer is the second leading cause of death in the United States. A cancer cell is genetically unstable and hence can mutate faster. They can also modify their microenvironment and escape immune surveillance. The difficulties in treating cancer are further compounded by the emergence of rapid resistance to anticancer drugs. The most common ways to attain resistance in cancer cells include alteration in drug transport and metabolism, modification of drug target, elevated DNA damage response, or...
3.7K