精神病学中深度大脑刺激中的睡眠差距:系统性审查
Zachary L Bernstein1, Joseph N Abergel1, David Cowan1
1Department of Neurosurgery, Emory University School of Medicine, 1365 Clifton Road NE, Atlanta, GA 30322, USA.
Clinical neurology and neurosurgery
|November 9, 2025
概括
针对精神疾病的深度大脑刺激 (DBS) 对睡眠结果的研究有限. 目前的数据不足以确定DBS.
科学领域:
- 神经科学是一个神经科学.
- 精神病学是一个精神病学.
- 睡眠医学 睡眠医学
背景情况:
- 深度大脑刺激 (DBS) 是治疗耐药精神疾病的一种有前途的治疗方法.
- 睡眠显著影响精神健康,但它在DBS患者中的作用尚不清楚.
研究的目的:
- 系统地审查和量化报告睡眠影响在患者接受DBS精神病症候群的研究.
- 总结DBS对精神病患者睡眠质量和睡眠模式所报告的影响.
主要方法:
- 使用PubMed进行了系统的文献搜索,使用有关DBS和精神疾病的MeSH术语进行了系统的文献搜索.
- 纳入标准包括人类研究 (病例报告,系列,队列,试验),调查精神疾病的DBS.
- 302项研究符合3873项初步查的纳入标准.
主要成果:
- 大多数包括的研究都集中在强迫症和抑郁症上.
- 睡眠评估方法有很大差异,包括主观尺度 (例如PSQI,HDRS子尺度),不良事件报告,可穿戴监视器和生理记录 (LFP,EEG).
- 在13项报告睡眠结果的研究中,5项表明睡眠改善,2项报告睡眠恶化,6项没有发现显著影响.
结论:
- 在精神疾病的DBS研究中,标准化睡眠结果测量显著缺乏.
- 目前的证据有限且不足,因此无法确定DBS对这些患者睡眠的影响.
- 标准化的睡眠评估对于未来的DBS研究至关重要,以阐明它对精神病学的影响.
相关概念视频
Sleep-Wake Cycles
Sleep is an essential physiological process vital to maintaining overall well-being. The reticular activating system (RAS), a network of neurons in the brainstem, regulates wakefulness and sleep. While it may seem passive, sleep consists of distinct cycles, each with its unique characteristics and functions. Two key sleep phases are non-rapid eye movement (NREM) and rapid eye movement (REM).
NREM Sleep
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NREM Sleep
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REM Sleep Behavior Disorder
REM Sleep Behavior Disorder (RBD) is a sleep disorder characterized by the absence of muscle paralysis that normally occurs during the REM phase of sleep. This absence allows individuals to physically act out their dreams, which are often vivid and disturbing. Common behaviors exhibited during episodes include kicking, punching, and yelling. These actions can be dangerous, potentially leading to injuries for the person with RBD or their bed partner.
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Narcolepsy is a chronic sleep disorder characterized by pervasive, uncontrolled sleepiness and other sleep disturbances. One of its hallmark symptoms is an abrupt transition to REM sleep upon falling asleep, which causes symptoms typically associated with this phase to occur unexpectedly during wakefulness. These include the following symptoms, which typically last from a minute or two to half an hour.
Substance Use Disorders Affecting Sleep
Substance use disorders involve a pattern of using drugs more extensively than intended and continuing use despite harmful consequences. This includes legal substances like alcohol and nicotine, as well as illegal drugs. These disorders often involve both physical and psychological dependence, reflecting compulsive use of substances that significantly alter thoughts, feelings, and behaviors, contributing to a major public health issue.
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