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通过DNA甲基化钟测量生物年龄和脆弱性:系统性审查和元分析
Jian Hua Tay1, Duarte Barros2, Weilan Wang1
1NUS Academy for Healthy Longevity, Yong Loo Lin School of Medicine, National University of Singapore, Singapore; Healthy Longevity Translational Research Programme, Yong Loo Lin School of Medicine, National University of Singapore, Singapore.
The lancet. Healthy longevity
|November 9, 2025
概括
表观遗传年龄加速 (EAA) 度量,特别是灰色年龄EAA,与脆弱性有关. 这一系统性审查强调了GrimAge EAA作为脆弱的持续预测指标,表明其早期干预的潜力.
科学领域:
- 老年学是指老年学的学科.
- 表观遗传学 在表观遗传学中,表观遗传学是指表观遗传学.
- 衰老的生物标志物
背景情况:
- 虚弱是一种与年龄相关的疾病,涉及生理衰退,增加对不良健康结果的脆弱性.
- 衰老的生物标志物,包括基于DNA甲基化的指标,可能有助于识别有风险的个体,以便进行早期干预.
- 这项研究系统地审查了基于DNA甲基化的生物年龄指标和脆弱性之间的关联.
研究的目的:
- 检查基于DNA甲基化的生物年龄指标与脆弱性之间的横截面和纵向关联.
- 调查DNA甲基化年龄,表观遗传年龄加速 (EAA) 和年龄偏差与脆弱性之间的关系.
- 综合基于人口的队列研究的证据.
主要方法:
- 对六个数据库 (2011年1月至2025年6月) 进行系统搜索相关的基于人口的队列研究.
- 包括的研究报告了DNA甲基化年龄,EAA或年龄偏差和脆弱性之间的关联.
- 对标准化β系数和SE进行了随机效应元分析,并进行了偏差风险评估.
主要成果:
- DNA甲基化年龄和年龄偏差与脆弱性没有显著关联.
- 更高的Hannum EAA,PhenoAge EAA,GrimAge EAA和衰老速度与横截面分析中的更高的脆弱性有关.
- 较高的灰色年龄EAA在纵向分析中显著与脆弱性增加有关.
结论:
- GrimAge表观遗传年龄加速始终与更高的脆弱性有关.
- 未来的研究应该专注于开发和验证用于脆弱性预测的DNA甲基化钟.
- 经过验证的甲基化钟的临床翻译可以使早期的脆弱性干预成为可能.
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