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长期高盐饮食会通过肠道微生物群的改变引起认知障碍和焦虑

Wenting Xu¹, Chenglin Zhang², Yudan Bai¹

¹Department/Institute of Neurobiology, School of Basic Medical Sciences, Xi'an Jiaotong University Health Science Center, Xi'an, 710061, China; Key Laboratory of Ministry of Education for Environment and Genes Related to Diseases, Xi'an Jiaotong University Health Science Center, Xi'an, 710061, China.

European journal of pharmacology

|November 9, 2025

概括

高盐饮食会通过改变肠道细菌和大脑基因表达来引起小鼠的认知和焦虑问题,导致神经炎症和神经元损伤.

科学领域:

神经科学是一个神经科学.
微生物学微生物学
遗传学是一个遗传学.

背景情况:

高盐饮食 (HSD) 与认知障碍和焦虑有关.
肠道微生物群的改变是这些影响的潜在机制.

研究的目的:

研究慢性HSD对小鼠认知,焦虑,肠道微生物群和海马基因表达的影响.
探索肠道微生物群变化与海马基因表达之间的相关性.

主要方法:

在180天的时间里,小鼠被食高盐饮食 (8% NaCl) 或控制饮食 (0.4% NaCl).
行为测试评估了认知和类似焦虑的行为.
RT-qPCR分析了海马神经炎症,Nissl/NeuN染色量化了神经元损伤.
相关性分析将肠道微生物组成与海马基因表达联系起来.

主要成果:

在小鼠中,HSD损害了认知和情绪行为.
观察到肠道微生物群的显著变化:多布西埃拉和亚热质细胞增加,减少Prevotellaceae_UCG_001.
HSD调节海马基因表达,对Btbd16,Il1b,Prlr,Cd24a,Ak7进行上调,对Casp4.4进行下调.
在特定的肠道细菌和海马基因 (例如,Dubosiella与Il1b/Cd24a) 之间发现了相关性.

结论:

慢性HSD诱导肠道失调,并改变海马基因表达.
这些变化促进海马神经炎症和神经元损伤,导致认知缺陷和焦虑.
这项研究提供了通过肠-大脑轴中断来了解HSD诱导的认知障碍的机制.

关键词:

认知障碍认知障碍是一种认知障碍.我们的肠道微生物群.高盐的饮食高盐饮食在海马体内,海马体神经元受损的情况.

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