,和与德国门诊患者的肝功能标志物的关联
Jiao Zuo1, Katrin Huesker2, Xin Chen3
1Fifth Department of Medicine, University Medical Center Mannheim, University of Heidelberg, Mannheim, Germany; Charité Universitätsmedizin Berlin, Berlin, Germany.
概括
长期暴露于有毒金属如,和,可能会损害肝功能. 是最强大的肝毒素,即使在较低的环境水平上也会影响肝酶.
科学领域:
- 环境健康 环境健康
- 毒理学 毒理学 毒理学
- 肝病学 肝病学是一种肝病学.
背景情况:
- 众所周知,长期暴露于,和会损害肝功能.
- 这些金属对肝酶的综合影响,特别是在背景暴露水平下,还不清楚.
研究的目的:
- 研究,和对肝酶的独立和协同作用.
- 评估背景金属暴露对肝细胞 (AST,ALT) 和胆固醇 (ALP) 肝酶的影响.
主要方法:
- 分析了来自58,864名没有已知的毒性暴露的德国门诊患者的数据.
- 测量血液中,和的含量.
- 根据年龄和性别调整的多变量模型,包括相互作用术语,以评估与AST,ALT和ALP的关联.
主要成果:
- 与ALT呈现最强的正相关性,表明具有显著的肝细胞效应.
- 与AST和ALT的增加和ALP的降低有关,这表明肝细胞和胆固醇效应.
- 与所有肝脏酶的积极关联较弱,但显著. 同时暴露的分析显示了显著的相互作用,和的联合增加ALT和降低ALP,和的联合增加AST.
结论:
- 暴露在有毒金属的背景中,即使低于职业值,也会微妙地损害肝功能.
- 在研究的金属中,被确定为最强大的肝毒素.
- 研究结果表明,需要重新评估环境安全标准,特别是在对金属的联合暴露方面.
相关概念视频
01:22Effect of Hepatic Disease on Pharmacokinetics: Pathophysiologic Assessment and Liver Function Test
171
In clinical practice, the direct measurement of hepatic blood flow to evaluate liver function presents significant challenges due to the intricate and specialized nature of the necessary techniques. Consequently, healthcare professionals often rely on empirical estimates derived from thorough patient examinations and liver function tests to gauge liver health. Among the tools at their disposal, the Child–Pugh and MELD scoring systems stand out for their ability to categorize and assess...
171
01:27The Periodic Table and Organismal Elements
22.1K
Elements are the smallest units of matter that cannot be broken down further by chemical processes. There are 118 known elements, but not all of these are naturally occurring, and only a few of them are essential for life. Living matter is composed primarily of carbon, nitrogen, hydrogen, and oxygen, with smaller amounts of other elements like calcium, phosphorus, potassium, and sulfur. Other elements are also necessary for life but only in trace amounts.
Periodic Table Provides Information...
Periodic Table Provides Information...
22.1K