与轴向运动障碍相关的Anti-Yo抗体 - - ANNS中的新型表型
Ajith Cherian1, Divya K P1, Amod R1
1Department of Neurology, Sree Chitra Tirunal Institute of Medical Sciences and Technology, Trivandrum, Kerala 695011, India.
Immunology letters
|November 9, 2025
概括
反抗体可以导致老年人罕见的运动障碍. 虽然往往抗治疗,但一些患者显示显著改善免疫疗法,强调了早期诊断的必要性.
科学领域:
- 神经学 神经学
- 免疫学 免疫学 免疫学
- 神经免疫学 神经免疫学
背景情况:
- 运动障碍通常与抗神经元抗体介导的神经综合征 (ANNS) 有关.
- 虽然ANNS通常与抗CV2 / CRMP5,Hu / ANNA1和CASPR2等抗体相关,但与抗Yo抗体相关的运动障碍非常罕见.
- 这项研究侧重于运动障碍与抗Yo抗体的不频繁呈现.
研究的目的:
- 研究与抗Yo抗体相关的运动障碍的临床特征和治疗结果.
- 确定在患有运动障碍的患者中暗示ANNS的关键特征.
主要方法:
- 在5年的时间里 (2019-2024) 分析了47名抗Yo抗体患者的数据.
- 纳入标准侧重于运动障碍表型的患者,不包括动力衰竭和其他潜在病因.
- 案例研究方法详细介绍了两个特定患者的呈现和管理.
主要成果:
- 两名老年男性 (六十多岁) 呈现了亚急性,渐进的轴向运动障碍和阳性抗Yo抗体.
- 一名患者经历了轴性肌和坎普托科尔米亚,在最初对类固醇无反应后,IV免疫球蛋白和瑞图西马布显著改善.
- 第二名患者对治疗的反应不足于最佳水平.
结论:
- 在老年患者 (>50岁) 中,亚急性,渐进性运动障碍 (持续时间>3个月),特别是疼痛和体内症状,应引起ANNS的怀疑.
- 与表面抗原介导的ANNS相比,针对细胞内抗原的Anti-Yo抗体诱导的ANNS通常在免疫调节疗法下具有谨慎的预后.
- 尽管预后通常是谨慎的,但可能会出现显著的治疗反应,正如在其中一个报告的病例中所示.
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