甲化物通过调节/酸同载体的作用,在怀孕的老鼠中抑制了甲状腺激素
Celigeer1, Wei Tian2, Zongzhen Wu2
1Department of Pharmacy, People's Hospital of Xinjiang Uygur Autonomous Region, Urumqi, Xinjiang, PR China.
Toxicology letters
|November 9, 2025
概括
甲化物是一种流行的植物生长调节剂,通过在怀孕期间抑制TSH-PKA-NIS通路来破坏孕产妇甲状腺激素 (THs) 并影响大鼠后代的大脑体重.
科学领域:
- 内分泌学 在内分泌学.
- 发育毒理学 发展毒理学
- 农业科学 农业科学
背景情况:
- 甲化物是一种广泛使用的植物生长调节剂,可提高作物产量.
- 以前的研究表明,对母体和胚胎的恒温有潜在影响.
- 了解其在怀孕期间的影响至关重要,因为人类的广泛暴露.
研究的目的:
- 为了研究甲化物暴露在怀孕大鼠上的影响.
- 阐明观察到的激素和发育变化背后的机制.
- 评估对母亲甲状腺激素合成和后代发育的影响.
主要方法:
- 怀孕的老鼠从怀孕日0-20分钟口服了不同剂量的甲 (0-5mg/kg.bw).
- 孕妇的甲状腺激素水平在怀孕第11天被测量.
- 甲状腺组织分析了/合载体 (NIS) 表达和相关信号通路 (TSH,PKA).
- 后代的脑体重在出生后的第10天被评估.
主要成果:
- 孕期第11天,母亲的甲状腺激素水平显著抑制.
- 甲基化物剂量依赖地抑制了怀孕大鼠的/同载体 (NIS).
- 甲状腺激素 (TSH) 诱导的cAMP依赖蛋白激酶A (PKA) 信号通路调节NIS也被抑制.
- 这种途径的抑制特异性是怀孕的老鼠,没有观察到非怀孕的雌性.
- 后代的脑体重在出生后的第10天受到影响.
结论:
- 甲基化物降低了NIS的调节,抑制了孕妇在怀孕期间的甲状腺激素合成.
- 这种干扰会影响胚胎发育,并导致后代的出生后大脑体重发生变化.
- 在妊娠期间,TSH-PKA-NIS通路是甲化的关键标.
相关概念视频
Synthesis and Regulation of Thyroid Hormones
7.1K
Low blood levels of the thyroid hormones — triiodothyronine (T3) and thyroxine (T4) — signal the hypothalamus to release the thyrotropin-releasing hormone (TRH). TRH then reaches the pituitary gland and stimulates the release of thyroid-stimulating hormone(TSH) into the bloodstream.
Upon reaching the thyroid gland, TSH stimulates the follicular cells' active uptake of iodide ions from the blood. The ions diffuse to the apical surface of the cells and are oxidized to iodine. The...
Upon reaching the thyroid gland, TSH stimulates the follicular cells' active uptake of iodide ions from the blood. The ions diffuse to the apical surface of the cells and are oxidized to iodine. The...
7.1K
Functions of Thyroid Hormones
4.9K
The thyroid hormone (TH) plays a pivotal role in the intricate orchestration of physiological processes, exerting profound effects on development, metabolism, and homeostasis throughout different life stages.
TH is indispensable for the normal development and maturation of the skeletal, muscular, and nervous systems during fetal and childhood growth. It facilitates bone mineral turnover and regulates protein synthesis in developing tissues, contributing significantly to overall growth and...
TH is indispensable for the normal development and maturation of the skeletal, muscular, and nervous systems during fetal and childhood growth. It facilitates bone mineral turnover and regulates protein synthesis in developing tissues, contributing significantly to overall growth and...
4.9K
Antihypertensive Drugs: Thiazide-Class Diuretics
1.6K
Thiazide diuretics are sulfonamide derivatives featuring a benzothiadiazine ring system in their molecular structure. Based on this structure, thiazide diuretics can be categorized into two groups: thiazide-type and thiazide-like diuretics. Thiazide-type diuretics, including hydrochlorothiazide and chlorothiazide, consist of a benzothiadiazine backbone with an attached sulfonamide group. Thiazide-like diuretics, such as chlorthalidone and indapamide, lack the thiazide ring but demonstrate...
1.6K
Synthesis and Functions of Calcitonin
4.1K
Calcitonin, a vital polypeptide hormone, regulates calcium levels within body fluids. It is released by the parafollicular cells, also known as C cells, situated in the follicular epithelium of the thyroid gland. Calcitonin responds to fluctuations in blood calcium levels and the influence of gastrointestinal hormones like gastrin and cholecystokinin.
The exact mechanisms by which calcitonin operates in calcium homeostasis remain elusive, but its significance is evident in several vital...
The exact mechanisms by which calcitonin operates in calcium homeostasis remain elusive, but its significance is evident in several vital...
4.1K
Antiarrhythmic Drugs: Class III Agents as Potassium Channel Blockers
1.8K
Class III antiarrhythmic drugs are a group of medications that can prolong action potentials in the heart. They achieve this by blocking potassium channels or enhancing inward currents from sodium channels. However, these drugs have a unique property of "reverse use-dependence," which is most pronounced at slower heart rates and can lead to torsades de pointes—a specific type of arrhythmia. However, it is essential to note that excessive QT interval prolongation—a measure of...
1.8K
Hormonal Regulation
35.7K
The renin-aldosterone system is an endocrine system which guides the renal absorption of water and electrolytes, thus managing blood pressure and osmoregulation. Activation of the system begins in the kidneys with a small cluster of cells adjacent to the afferent and efferent blood vessels of the renal corpuscle. As the nephrons are filtering blood, juxtaglomerular cells monitor blood pressure. If they detect a decrease in pressure, they release the hormone renin into the bloodstream.
35.7K


