评估上部胃肠道pH的动态性质:使用液体吸收技术进行聚合分析
Fritz Harder1, Joachim Brouwers1, Tim Vanuytsel2
1Drug Delivery and Disposition, KU Leuven, Herestraat 49 box 921, 3000 Leuven, Belgium.
International journal of pharmaceutics
|November 9, 2025
概括
这项研究揭示了像质子抑制剂 (PPI) 这样的食物和药物如何随着时间的推移改变上部胃肠道 (GI) 的pH值. 了解这些动态的pH值变化对于口服药物开发和in silico建模至关重要.
科学领域:
- 胃肠病学 胃肠病学
- 药理动力学 药理动力学
- 药物运输 药物运输 药物运输
背景情况:
- 上部胃肠道的光线pH值是动态的,受到生理和药理因素的影响.
- 准确的pH分析对于预测口服药物吸收和疗效至关重要.
- 之前的研究往往缺乏在各种条件下提供全面的时间pH数据.
研究的目的:
- 在不同的条件下,编制和分析上部肠道的时间pH概况.
- 调查水/食物摄入和质子抑制剂 (PPI) 联合治疗对光线pH的影响.
- 提供支持优化口服剂型和in silico预测工具的数据.
主要方法:
- 对来自19项标准化临床研究的数据进行了聚合分析.
- 在胃腹腔,十二指肠和近腹肠中测量内pH值.
- 使用GAMLSS进行时间分析,对禁食,食 (Ensure Plus,高脂肪餐) 和服用埃索梅普拉联合药物的状态进行评估.
主要成果:
- 食状态pH档案与胃和十二指肠的禁食状态档案有显著差异.
- 一个高脂肪的食物显示了类似的pH值形状,以确保Plus,但与较低的中位数pH值.
- 与禁食状态相比,埃索梅普拉的同时使用会增加胃,十二指肠和阴的pH值.
结论:
- 时间上部GI pH 值随着食物摄入量和PPI使用而显著变化.
- 这些详细的pH档案为口服药物配方和设计提供了宝贵的见解.
- 这些数据可以提高 in silico 模型的准确性,用于预测胃肠道中的药物行为.
相关概念视频
Upper GI Series: Barium Swallow
1.5K
The Barium Swallow Study, or a Barium Esophagogram, is a diagnostic imaging method used to visualize the upper gastrointestinal (GI) tract, including the esophagus, stomach, and small intestine. It employs barium sulfate, a radiopaque contrast material, to provide clear images of the upper digestive system, helping to identify abnormalities, diseases, or structural issues.
Purpose and Procedure
Patients undergoing this procedure ingest a liquid containing barium sulfate with a chalky...
Purpose and Procedure
Patients undergoing this procedure ingest a liquid containing barium sulfate with a chalky...
1.5K
Assessment of the Gastrointestinal System I: Subjective Data
600
Assessing the gastrointestinal (GI) system is a complex process that begins with collecting subjective data. This data, collected through patient interviews, provides crucial insights into the patient's health history, perception patterns, and lifestyle habits, all contributing significantly to GI health.
Health History
The initial step in assessing the GI system is obtaining a comprehensive health history. This includes inquiring about the patient's history or presence of problems...
Health History
The initial step in assessing the GI system is obtaining a comprehensive health history. This includes inquiring about the patient's history or presence of problems...
600
Peptic Ulcer Disease III: Clinical Manifestations and Diagnostic Studies
522
Peptic ulcer disease (PUD) presents with diverse symptoms depending on the location and severity of the ulcer. Clinical manifestations of peptic ulcer include dull pain and a burning sensation in the mid-epigastric region.
Few clinical manifestations differentiate gastric ulcers from duodenal ulcers. Distinctions in the location, timing, and pain relief are crucial for healthcare providers in differentiating between gastric and duodenal ulcers during clinical assessments.
Few clinical manifestations differentiate gastric ulcers from duodenal ulcers. Distinctions in the location, timing, and pain relief are crucial for healthcare providers in differentiating between gastric and duodenal ulcers during clinical assessments.
522
Endoscopic Procedures I: Esophagogastroduodenoscopy
855
An Esophagogastroduodenoscopy (EGD) is a diagnostic procedure in which an endoscopist uses a flexible, lighted endoscope to visualize the upper gastrointestinal (GI) tract. The procedure includes visualizing the oropharynx, esophagus, stomach, and the first part of the small intestine, the duodenum.
During an EGD, the endoscope can be used to:
During an EGD, the endoscope can be used to:
855
Imaging Studies III: Gastrointestinal Motility Studies and Virtual Colonoscopy
357
This lesson explores three gastrointestinal imaging techniques: radionuclide testing, colonic transit studies, and virtual colonoscopy.
Radionuclide Testing
Radionuclide testing is a sophisticated medical technique for assessing gastrointestinal motility. It focuses on gastric emptying and colonic transit time. Radioactive markers track the movement of food through the digestive system, providing insights into gastrointestinal disorders.
In gastric emptying studies, a meal's liquid and...
Radionuclide Testing
Radionuclide testing is a sophisticated medical technique for assessing gastrointestinal motility. It focuses on gastric emptying and colonic transit time. Radioactive markers track the movement of food through the digestive system, providing insights into gastrointestinal disorders.
In gastric emptying studies, a meal's liquid and...
357
Lower GI Series: Barium Enema
1.3K
A Barium Enema, or a lower GI series, is a specialized radiographic examination designed to visualize the lower gastrointestinal tract, specifically the colon and rectum. This procedure is instrumental in diagnosing various conditions such as colorectal cancer, polyps, diverticulosis, and inflammatory bowel disease.
Procedure Details
The examination begins by inserting a lubricated rectal tube into the patient's rectum to administer a radiopaque barium solution. The barium flow is carefully...
Procedure Details
The examination begins by inserting a lubricated rectal tube into the patient's rectum to administer a radiopaque barium solution. The barium flow is carefully...
1.3K


