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左心室壁厚度和心脏amyloidosis中的衍生参数

Michel Chedid El Helou¹, J Emanuel Finet¹, Joseph Kassab¹

¹Department of Cardiovascular Medicine, Cleveland Clinic, Cleveland, OH, United States of America.

Progress in cardiovascular diseases

|November 9, 2025

概括

心脏粉症 (CA) 显示左心室壁厚度 (LVWT) 变化,通常是正常的,特别是在女性中. 相对墙壁厚度 (RWT) 提高了早期CA检测,尽管测量变化.

科学领域:

心脏病学心脏病学
医疗成像医学成像
诊断工具诊断工具

背景情况:

左心室壁厚度 (LVWT) 对于诊断心肌粉症 (CA) 是至关重要的.
传统的LVWT值可能无法检测早期的CA.
了解跨甲状腺素 (ATTR-CA) 和轻链 (AL-CA) 中的LVWT频谱至关重要.

研究的目的:

在ATTR-CA和AL-CA中描述LVWT的范围和衍生参数.
在CA诊断中评估RWT和LVMi的灵敏度.
评估LVWT测量的性别差异和观察者变异性.

主要方法:

对1845名CA患者 (2006-2024) 的回顾性分析.
对LVWT,RWT和左心室质量指数 (LVMi) 的心声评估.
检查性别差异和观察者之间的/观察者内部的变异性.

主要成果:

相当一部分CA患者的LVWT正常或轻微增加 (≤1.2厘米),包括13%的AL-CA和6.5%的ATTR-CA.
12.2%的AL-CA患者表现出明显升高的LVWT (>2.0厘米).
相对墙壁厚度 (RWT) 对于CA检测比LVMi更敏感,并且没有性别差异;观察者发现了实质性的变化 (SE ~ 1.5 mm).

结论:

心脏粉症 (CA) 呈现出广泛的LVWT,通常在正常范围内,特别是在女性中.
相对壁厚 (RWT) 显示了对CA检测的更高灵敏度,可能有助于早期诊断.
显著的观察者变异性需要标准化和使用衍生指标,以提高心声回声学诊断的准确性.

关键词:

心脏氨基粉症症的心脏粉症心声回声扫描 (Echocardiography) 是一种心声回声扫描.左心室壁的厚度左心室壁的厚度观察者可变性观察者可变性性差异性差异性差异性差异性差异性差异性差异性

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