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Updated: Jan 11, 2026

Development of Inhibitors of Protein-protein Interactions through REPLACE: Application to the Design and Development Non-ATP Competitive CDK Inhibitors
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最近在开发ATR抑制剂作为抗癌剂方面取得了进展

Shaohua Hou1, Yu Sun1, Lingyun Zhou1

  • 1School of Pharmacy, Wannan Medical College, Wuhu 241002 Anhui, PR China.

Biochemical pharmacology
|November 9, 2025
PubMed
概括

ATAXIA telangiectasia突变和Rad3相关 (ATR) 激酶对于基因组稳定性和癌症治疗至关重要. 本综述详细介绍了ATR抑制剂,它们的设计,以及用于增强癌症治疗的临床进展.

关键词:
作为ATR抑制剂的使用者.这是一种抗癌药物.对DNA损伤的反应反应药物设计 药物设计合成杀伤性 合成杀伤性

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