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Updated: Jan 11, 2026

Measuring Enzymatic Activity of Neurodevelopmental Disorder-Associated Deubiquitylating Enzymes via an In Vitro Ubiquitin Chain Cleavage Assay
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Measuring Enzymatic Activity of Neurodevelopmental Disorder-Associated Deubiquitylating Enzymes via an In Vitro Ubiquitin Chain Cleavage Assay

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非催化性UBL2域将duebiquitinaseUSP11引导到与K48结合的多比基因链

Sin-Rong Lee1, Han-Hsiun Chen1, Ruey-Hwa Chen1

  • 1Institute of Biological Chemistry, Academia Sinica, Taipei, Taiwan; Institute of Biochemical Sciences, College of Life Science, National Taiwan University, Taipei, Taiwan.

The Journal of biological chemistry
|November 9, 2025
PubMed
概括

在USP11蛋白中的UBL2域是它选择性地切割K48连接的泛素链的关键. 这一发现有助于开发针对USP11相关疾病的向疗法,例如癌症和神经退行.

关键词:
在diffdock上设置一个扩展码头.K48 - 链接链接在UBL2中,UBL2是UBL2.USP1 USP1 的时间没有二维基因酸酶.聚比基的链条链条

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