手脚综合征预防:药理干预-系统性审查和网络元分析
Manit Saeteaw1, Thanaporn Thippharak2, Komkrit Porasuntisuk2
1Clinical Pharmacy, Khon Kaen University, Nai Mueang, Thailand manitsa@kku.ac.th.
BMJ supportive & palliative care
|November 9, 2025
概括
在化疗期间,局部用迪克洛菲纳克有效地预防手脚综合征 (HFS),减少中度至重度和所有级别的HFS发病率. 这种干预也尽量减少化疗剂量修改,提供了优越的保护策略.
科学领域:
- 在瘤学瘤学.
- 皮肤病学 皮肤病学
- 药理学 药理学是指药理学的学科.
背景情况:
- 手脚综合征 (HFS) 是一种常见的化疗副作用.
- 凯普西塔和基化脂质体多克索鲁比是关键的致病剂.
- 目前正在积极研究HFS的预防策略.
研究的目的:
- 为了比较HFS预防的药理干预措施.
- 为了评估局部狄克洛芬雅克与其他药物的疗效.
- 进行网络元分析 (NMA),以获得可靠的证据.
主要方法:
- 在PubMed,Cochrane和Scopus的系统文献搜索.
- 包括随机对照试验 (RCT) 到2024年11月.
- 网络元分析以估计HFS发病率和化疗修改的风险比率 (RR).
主要成果:
- 分析了1983名患者的13个RCT.
- 局部使用的迪克洛菲纳克和赛莱科西布显著降低了中度至重度的HFS.
- 局部用迪克洛菲纳克独特地降低了所有级别的HFS和化疗修饰.
结论:
- 局部用迪克洛芬雅克提供了最有效的HFS预防.
- 它与更少的化疗修改有关.
- 考虑局部二二作为HFS的首选预防策略.
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