压力高血糖比率与创伤患者多器官功能障碍综合征发生率之间的关联:一个回顾性队列研究
Han Li1, Jinyu Peng1, Zhi Mao2
1Chinese PLA Medical School, Beijing 100853, China; Department of Critical Care Medicine, The First Medical Center, Chinese PLA General Hospital, Beijing 100853, China.
Injury
|November 9, 2025
概括
在没有糖尿病的创伤患者中,较高的压力高血糖比率 (SHR) 显著增加了患多器官功能障碍综合征 (MODS) 的风险. 这种关联在糖尿病创伤患者中没有发现.
科学领域:
- 临界护理医学 临界护理医学
- 创伤外科 手术 创伤外科
- 内分泌学 在内分泌学.
背景情况:
- 创伤引发显著的生理压力,可能导致多器官功能障碍综合征 (MODS).
- 压力高血糖比 (SHR) 是身体应激反应的标志物.
- 了解创伤中MODS的预测因素对于患者的治疗结果至关重要.
研究的目的:
- 调查压力高血糖比率 (SHR) 与创伤患者多器官功能障碍综合征 (MODS) 的发展之间的关联.
- 为了比较糖尿病与非糖尿病创伤患者队列中的这种关联.
主要方法:
- 从MIMIC-IV (3.1) 数据库中对784名创伤患者的回顾性分析.
- 患者被分为糖尿病患者和非糖尿病患者组,然后按SHR分层分层.
- 后勤回归和受限立方线 (RCS) 用于分析在ICU入院7天内SHR和MODS之间的关联.
主要成果:
- 在非糖尿病患者中,较高的SHR与MODS风险增加显著相关 (调整后OR=2.10).
- RCS分析证实了非线性,增加了MODS的风险,在这个群体中,SHR高的三角动物具有更高的MODS风险.
- 在糖尿病创伤患者组中没有观察到SHR和MODS之间的显著关联.
结论:
- 升高的SHR是非糖尿病创伤患者中MODS的显著预测因素.
- 对于MODS的SHR的预测值在糖尿病和非糖尿病创伤人群之间有所不同.
- 进一步的研究可能会探索这种差异性关联背后的机制.
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