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日本儿童核桃诱导过敏症的11年趋势:一项多中心回顾性研究
Yuna Iwashita1,2, Naoki Kajita3, Koichi Yoshida3
1Department of Pediatrics, Machida Municipal Hospital, Tokyo, Japan.
概括
导致过敏的核桃过敏的发病率在日本显著增加,特别是在幼儿中. 这一趋势凸显了对儿童食物过敏的日益关注.
科学领域:
- 儿科过敏和免疫学
- 食品安全与公共卫生问题
- 过敏疾病的流行病学
背景情况:
- 核桃过敏的全球流行率上升.
- 核桃引起的过敏反应的不清楚的趋势和临床特征.
- 需要评估发病率和患者人口统计数据的变化.
研究的目的:
- 评估日本核桃引起的过敏反应发生率的变化.
- 评估患者的特征和与核桃过敏相关的症状.
- 将核桃引起的过敏症与对其他食物的过敏症进行比较.
主要方法:
- 对于食物诱导的过敏反应 (2011-2021) 的儿科急诊室访问的回顾性研究.
- 使用Cochran-Armitage趋势测试对致病性食物比例的分析.
- 核桃和其他食物过敏症组之间的患者人口统计和症状的比较.
主要成果:
- 2011年至2021年间,核桃过敏发生率从3.2%上升至26.1% (p < .0001).
- 其他食物过敏的发病率没有显著变化.
- 胃肠道症状在核桃组 (72.5%) 比其他组 (55.9%) 更频繁.
- 在核桃组中,先前诊断的比例较低 (28.8%),而不是其他食物组 (47.4%).
结论:
- 日本自2010年代末以来,核桃诱导过敏症的快速增加.
- 这一趋势在幼儿中尤为明显.
- 许多病例代表了对核桃的第一次反应.
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