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相关概念视频

Chemical Shift: Internal References and Solvent Effects01:17

Chemical Shift: Internal References and Solvent Effects

1.2K
In an NMR sample, precise measurement of the absolute absorption frequencies of nuclei is difficult. A standard internal reference compound is added, and the frequency difference between the reference signal and sample signals is measured.
The internal reference compound generally used in NMR spectroscopy is tetramethylsilane (TMS). TMS is preferred because it is chemically inert, soluble in NMR solvents, and easily removable. Also, the highly shielded methyl protons in TMS yield an intense...
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¹H NMR: Interpreting Distorted and Overlapping Signals01:02

¹H NMR: Interpreting Distorted and Overlapping Signals

1.5K
Spin systems where the difference in chemical shifts of the coupled nuclei is greater than ten times J are called first-order spin systems. These nuclei are weakly coupled, and their chemical shifts and coupling constant can generally be estimated from the well-separated signals in the spectrum.
As Δν decreases and the signals move closer, the doublets appear increasingly distorted. The intensities of the inner lines increase at the cost of those of the outer lines as the signals are...
1.5K
¹³C NMR: Distortionless Enhancement by Polarization Transfer (DEPT)01:20

¹³C NMR: Distortionless Enhancement by Polarization Transfer (DEPT)

1.6K
When proton-coupled carbon-13 spectra are simplified by a broadband proton decoupling technique, structural information about the coupled protons is lost. Distortionless enhancement by polarization transfer (DEPT) is a technique that provides information on the number of hydrogens attached to each carbon in a molecule. While the DEPT experiment utilizes complex pulse sequences, the pulse delay and flip angle are specifically manipulated. The resulting signals have different phases depending on...
1.6K
2D NMR: Overview of Homonuclear Correlation Techniques01:16

2D NMR: Overview of Homonuclear Correlation Techniques

604
Homonuclear correlation spectroscopy (COSY) is a powerful technique used in Nuclear Magnetic Resonance (NMR) spectroscopy to study the correlations between nuclei of the same type within a molecule. It provides information about scalar couplings between adjacent nuclei, which helps determine connectivity and structural information. There are several COSY variants, each with its unique strengths and experimental parameters.
COSY90 is the standard two-dimensional (2D) COSY experiment that...
604
¹³C NMR: ¹H–¹³C Decoupling01:04

¹³C NMR: ¹H–¹³C Decoupling

1.7K
The probability of having two carbon-13 atoms next to each other is negligible because of the low natural abundance of carbon-13. Consequently, peak splitting due to carbon-carbon spin-spin coupling is not observed in spectra. However, protons up to three sigma bonds away split the carbon signal according to the n+1 rule, resulting in complicated spectra.
A broadband decoupling technique is used to simplify these complex, sometimes overlapping, signals. Broadband decoupling relies on a...
1.7K
Applications Of NMR In Biology01:25

Applications Of NMR In Biology

4.4K
Nuclear magnetic resonance (NMR) spectroscopy is a very valuable analytical technique for researchers. It has been used for more than 50 years as an analytical tool. F. Bloch and E. Purcell formulated NMR in 1946 and won the 1952 Nobel Prize in Physics  for their work. Biological macromolecules such as proteins, nucleic acids, lipids, and organic molecules including pharmaceutical compounds, can be studied using this versatile tool that exploits the magnetic properties of certain nuclei.
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Atomic Scale Structural Studies of Macromolecular Assemblies by Solid-state Nuclear Magnetic Resonance Spectroscopy
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用NMR探针进行动态场监测的数据拼接.

Jinyuan Zhang1,2,3, Zihao Zhang1,2,3, Zhentao Zuo1,3

  • 1State Key Laboratory of Cognitive Science and Mental Health, Institute of Biophysics, Chinese Academy of Sciences, Beijing, China.

Magnetic resonance in medicine
|November 9, 2025
PubMed
概括

一种新的接方法准确地描述了MRI序列中的磁场动态,从而实现了更高分辨率的成像. 这种技术即使在标准方法失败时也起作用,在超高电场下改善图像重建.

关键词:
这是一个二维螺旋螺旋.动态现场监控 动态现场监控高级的MR模拟模型.高级图像重建的图像重建.螺旋成像技术的使用

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Paramagnetic Relaxation Enhancement for Detecting and Characterizing Self-Associations of Intrinsically Disordered Proteins
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科学领域:

  • 磁共振成像 (MRI) 是一种磁共振成像技术.
  • 生物物理学的生物物理.
  • 医学物理 医学物理

背景情况:

  • 在MRI中标准的场域监测受到分辨率和读数长度的限制.
  • 描述动态磁场对于先进的MRI测序至关重要.

研究的目的:

  • 提出一种新的拼接方法,以提高分辨率和读出长度来表征MRI序列.
  • 克服标准现场监测方法的局限性.

主要方法:

  • 一种拼接方法,将分段特定的动态场测量与连续的TR相结合.
  • 使用2D螺旋序列在10.5T和7T与模拟和实验MRI数据进行演示.
  • 在7T的人类大脑成像中得到验证,并与梯度冲动响应函数 (GIRF) 预测进行比较.

主要成果:

  • 拼接方法在10.5T的标准方法中表现出色,提供了准确的动态场测量.
  • 在7T时,它产生了与标准方法相比的结果,如果适用,和标准方法失败时的合理测量.
  • 改善了7T对模拟和实验MRI数据的图像重建.

结论:

  • 拟议的拼接方法有效地描述了使用商业硬件具有挑战性的成像梯度.
  • 它不假设线性梯度系统,为超高分辨率MRI在超高场度提供广泛的实用性.