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通过患者衍生异种移植的基因组分析来解读癌症进化,以及匹配的初级胆囊癌

Vipin Yadav1, Ragini Kilambi2, Archana Rastogi3

  • 1Department of Molecular and Cellular Medicine, Institute of Liver and Biliary Sciences, D1 Vasant Kunj, New Delhi, 110070, India.

Digestive diseases and sciences
|November 9, 2025
PubMed
概括

建立了一种患者衍生异种移植 (PDX) 型胆囊腺素状癌的模型. 这种由KRAS (G12V) 突变驱动的模型有助于研究瘤进化和识别潜在的癌症干细胞.

关键词:
状腺癌 (Adenosquamous carcinoma) 是一种状腺癌.克隆的演化过程中的克隆进化.遗传景观 遗传景观 遗传景观来自患者的异种移植.预后标志物是一个预后标志物.

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