医生对非标签用途的不支持数据的感知和意图:一项与初级保健提供者和瘤学家的实验研究
Kathryn J Aikin1, Simani M Price2, Amie C O'Donoghue3
1Office of Prescription Drug Promotion, Center for Drug Evaluation and Research, U.S. Food and Drug Administration, Silver Spring, MD, 27614, USA. kathrynaikin12@gmail.com.
Therapeutic innovation & regulatory science
|November 9, 2025
概括
披露关于非标签药物使用的不支持数据增加了对处方决定的感知重要性. 具体的披露对初级保健提供者来说更有用,而瘤学家则打算在被告知可能存在其他数据时进行更多的搜索.
科学领域:
- 医学科学 医学科学 医学科学
- 临床药房 临床药房
- 基于证据的医学基于证据的医学.
背景情况:
- 医生对非标签药物使用证据的认识影响了处方决策.
- 了解如何披露不支持的数据对于知情的医疗实践至关重要.
研究的目的:
- 测试不同的方法,揭露非标签药物使用的不支持证据.
- 评估这些披露对医生的看法和信息搜索意图的影响.
主要方法:
- 初级保健提供者和瘤学家审查了关于非标签药物使用的报告 (治疗失眠的特拉佐,治疗恶性虫的伊米基莫德).
- 测试了四种披露变化 (完整报告,摘要+引用,引用,其他数据的陈述) 以及一个控制.
- 参与者评价了信息在规定决策中的有用性和重要性,以及他们打算寻求更多数据的意图.
主要成果:
- 任何不支持数据的披露都会增加与不披露相比的感知重要性.
- 具体披露对于初级保健提供者来说更有用;瘤学家表现出越来越多的意图通过一般披露进行搜索.
- 常见的非标签处方者和那些有先前经验的人低估了信息的重要性.
结论:
- 关于不支持非标签药物使用数据的披露对于处方至关重要.
- 在非标签处方方面有更多经验的医生可能会低估这种信息.
- 根据受众量身定制披露的具体性可以提高有效性.
相关概念视频
Nursing Ethical Principles II
2.1K
Ethical principles are essential in guiding nurses to fulfill their responsibilities, focusing on the quality of nursing care and decision-making. These principles, including autonomy, beneficence, non-maleficence, justice, and fidelity, shape the ethical framework within healthcare settings.
Consider the following scenario, which illustrates how these principles are applied in the care of Mr. John, a fifty-year-old teacher diagnosed with metastatic liver cancer.
Initially, Mr. John's...
Consider the following scenario, which illustrates how these principles are applied in the care of Mr. John, a fifty-year-old teacher diagnosed with metastatic liver cancer.
Initially, Mr. John's...
2.1K
Treatment Resistant Cancers
3.7K
Cancer is the second leading cause of death in the United States. A cancer cell is genetically unstable and hence can mutate faster. They can also modify their microenvironment and escape immune surveillance. The difficulties in treating cancer are further compounded by the emergence of rapid resistance to anticancer drugs. The most common ways to attain resistance in cancer cells include alteration in drug transport and metabolism, modification of drug target, elevated DNA damage response, or...
3.7K
Obedience
35.2K
According to obedience research, we may harm others under the forceful pressures of an authority figure (Milgram, 1974). How about if the inappropriate orders were delivered with less force? The increasing interdependence between nurses and physicians compelled Hofling and his colleagues to explore nurses’ reactions to a potentially harmful medical request made by the perceived authority figure, the doctor (Hofling, Brotzman, Dalrymple, Graves, & Pierce, 1966). In this situation,...
35.2K
Cancer Therapies
9.8K
Cancer therapies are various modes of treatment, such as surgery, radiation therapy, and chemotherapy that are administered to cancer patients.
However, cancer treatments can pose several challenges, as therapies used to kill cancer cells are generally also toxic to normal cells. Moreover, cancer cells mutate rapidly and can develop resistance to chemical agents or radiation therapy. Besides, all types of cancer cells may not respond to the same therapy. Some cancer cells respond to one...
However, cancer treatments can pose several challenges, as therapies used to kill cancer cells are generally also toxic to normal cells. Moreover, cancer cells mutate rapidly and can develop resistance to chemical agents or radiation therapy. Besides, all types of cancer cells may not respond to the same therapy. Some cancer cells respond to one...
9.8K
The Placebo Effect
6.8K
The placebo effect occurs when people's expectations or beliefs influence or determine their experience in a given situation. In other words, simply expecting something to happen can actually make it happen.
6.8K
Combination Therapies and Personalized Medicine
5.9K
Combining two or more treatment methods increases the life span of cancer patients while reducing damage to vital organs or tissue from the overuse of a single treatment. Combination therapy also targets different cancer-inducing pathways, thus reducing the chances of developing resistance to treatment.
The combination of the drug acetazolamide and sulforaphane is a good example of combination therapy to treat cancer. The cells in the interior of a large tumor often die due to the hypoxic and...
The combination of the drug acetazolamide and sulforaphane is a good example of combination therapy to treat cancer. The cells in the interior of a large tumor often die due to the hypoxic and...
5.9K

